Current knowledge of mitochondrial biology and function has provided with tools and technologies that helped a better understanding of the molecular etiology of complex mitochondrial disorders. Dual genetic control of this subcellular organelle function regulates various signaling mechanisms which are essential for metabolism, bioenergetics, fatty acid biosynthesis, and DNA replication & repair. Understanding nuclear mitochondrial crosstalk through advanced genomics as well as clinical perspectives is the overall basis of mitochondrial research and medicine, also the sole objective of Society for Mitochondrial Medicine and Research (SMRM) - India. The eighth virtual international conference on ‘Advances in Mitochondrial Medicine and Translational Research’ was organized at the Manipal School of Life Sciences, MAHE, Manipal, India, during 6 – 7 November 2020. The aim of the virtual conference was to highlight the recent advances and future perspectives that represent comprehensive clinical and fundamental research interests in the area of mitochondrial biology of human diseases. To systematically present the various findings in mitochondrial biology, the meeting was themed with specific aspects comprising (a) mitochondrial disorders: clinical & genomic perspectives, (b) mitochondria in cancer, (c) mitochondrial metabolism & disorders, and (d) mitochondrial diseases & therapy. This report provides an overview of the recent advancements in the area of mitochondrial biology and medicine that was discussed at the conference.

目前对线粒体生物学和功能的了解提供了工具和技术，有助于更好地理解复杂线粒体疾病的分子病因学。这种亚细胞器功能的双重遗传控制调节着新陈代谢、生物能量学、脂肪酸生物合成以及 DNA 复制和修复所必需的各种信号机制。通过先进的基因组学和临床视角了解核线粒体串扰是线粒体研究和医学的总体基础，也是印度线粒体医学与研究学会 (SMRM) 的唯一目标。第八届虚拟国际会议“线粒体医学和转化研究进展”于 2020 年 11 月 6 日至 7 日在印度马尼帕尔 MAHE 马尼帕尔生命科学学院举办。此次虚拟会议的目的是强调最新进展以及代表人类疾病线粒体生物学领域综合临床和基础研究兴趣的未来观点。为了系统地展示线粒体生物学的各种发现，会议的主题包括（a）线粒体疾病：临床和基因组观点，（b）癌症中的线粒体，（c）线粒体代谢和疾病，以及（d）线粒体疾病＆ 治疗。本报告概述了会议上讨论的线粒体生物学和医学领域的最新进展。