Recently, Zhejiang University scientists developed a local “landmine.” They engineered a patch device consisting of microneedle arrays integrated with palladium nanoparticles supported by TiO₂ nanosheets to catalyze a local prodrug-into-drug conversion via bio-orthogonal reaction for tumor inhibition. This study provides a novel paradigm for biological application of bio-orthogonal chemistry in local tumor treatment.

中文翻译：

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可拆卸的生物正交催化贴片：当地的“地雷”

近日，浙江大学科学家研制出当地的“地雷”。他们设计了一种贴片装置，由微针阵列与由 TiO ₂纳米片支撑的钯纳米颗粒集成，以通过生物正交反应催化局部前药转化为药物，从而抑制肿瘤。该研究为生物正交化学在局部肿瘤治疗中的生物学应用提供了新的范例。