Background. Gastric cancer is the most common malignant tumor of the digestive system. It has a poor prognosis and is clinically challenging to treat. Ferroptosis is a newly defined mode of programmed cell death. The roles and prognostic value of ferroptosis-related long noncoding RNAs (lncRNAs) in gastric cancer remain unknown. Results. In the current study, 20 ferroptosis-related lncRNAs were identified via univariate Cox analysis, least absolute shrinkage, and selection operator Cox regression analysis and used to construct a prognostic signature and classify gastric cancer patients into high-risk and low-risk groups. The signature was validated using TCGA training and testing cohorts. The risk signature was an independent prognostic indicator of survival and accurately predicted the prognoses of patients with gastric cancer. It was also associated with immune cell infiltration. Gene set enrichment analysis was used to investigate underlying mechanisms that the 20 ferroptosis-related lncRNAs were involved in. Chemosensitivity and immune checkpoint inhibitor analyses indicated that high-risk patients were more sensitive to the immune checkpoint inhibitor programmed cell death protein 1. Conclusions. The important role of ferroptosis-related lncRNAs in immune infiltration identified in the current study may assist the determination of personalized prognoses and treatments in patients with gastric cancer. These 20 lncRNAs can be used as the diagnostic and prognostic markers for gastric cancer.

中文翻译：

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铁死亡相关长非编码 RNA 的鉴定和胃癌新预后特征的构建

背景。胃癌是消化系统最常见的恶性肿瘤。它的预后较差，临床上治疗具有挑战性。铁死亡是一种新定义的程序性细胞死亡模式。铁死亡相关的长非编码 RNA (lncRNA) 在胃癌中的作用和预后价值仍不清楚。结果。在本研究中，通过单变量Cox分析、最小绝对收缩和选择算子Cox回归分析鉴定了20种与铁死亡相关的lncRNA，并用于构建预后特征并将胃癌患者分为高风险组和低风险组。使用 TCGA 训练和测试队列验证签名。风险特征是生存的独立预后指标，可以准确预测胃癌患者的预后。它还与免疫细胞浸润有关。使用基因集富集分析来研究 20 个与铁死亡相关的 lncRNA 所涉及的潜在机制。结论。当前研究中确定的铁死亡相关lncRNA在免疫浸润中的重要作用可能有助于确定胃癌患者的个性化预后和治疗。这20个lncRNA可作为胃癌的诊断和预后标志物。