Dubois et al. report results of a meta-analysis assessing the diagnostic accuracy of rapid nucleic acid tests (RNATs) for group A Streptococcus (GAS) pharyngitis. While the accuracy of any diagnostic assay is crucial, the clinical application of these tests must be considered as these molecular assays become more widely implemented. We provide commentary to highlight the considerations for optimal use of RNATs in practice, taking into account the appropriate clinical context and setting to perform and evaluate these tests. Specifically, we address the critical clinical questions: “What is the benefit of rapid testing for GAS?” and “Under what circumstances should RNATs for GAS be utilized?”

杜布瓦等人。报告评估快速核酸检测 (RNAT) 对 A 组链球菌 (GAS) 咽炎的诊断准确性的荟萃分析结果。虽然任何诊断测定的准确性都至关重要，但随着这些分子测定的实施越来越广泛，必须考虑这些测试的临床应用。我们提供评论以强调在实践中最佳使用 RNAT 的考虑因素，同时考虑到执行和评估这些测试的适当临床背景和环境。具体来说，我们解决了关键的临床问题：“快速检测 GAS 有什么好处？” “在什么情况下应该使用 GAS 的 RNAT？”