ABSTRACT

Background

Neonatal sepsis is an important risk factor for lesions in the brain of preterm newborns (PTNB) and the most effective strategies to minimize its deleterious effects are early detection and intervention.

Aim

To investigate the presence of neurological abnormalities in PTNBs after neonatal sepsis.

Methods

This was a prospective cross-sectional study with 100 PTNBs selected at random, 50 of the study group (sepsis) and 50 of the control group (non-sepsis). The neurological evaluation protocol adopted was the Hammersmith Neonatal Neurological Examination (HNNE).

Results

The PTNBs of the sepsis group had total HNNE scores lower than expected for normality in 86% of the cases, and the non-sepsis group in 26% (p < .001). Higher prevalence levels of altered scores in tone category (p < .001), tone patterns (p = .026), reflexes (p = .002), movements (p < .001), abnormal signs (p < .001) and behavior (p < .001).

Conclusion

The neurological dysfunctions after neonatal sepsis could be identified by clinical neonatal neurological evaluation.

中文翻译：

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“新生儿败血症后早产儿临床检查的价值：一项横断面观察研究。”

摘要

背景

新生儿败血症是早产儿 (PTNB) 脑部病变的重要危险因素，将其有害影响降至最低的最有效策略是早期发现和干预。

目标

调查新生儿败血症后 PTNB 中是否存在神经系统异常。

方法

这是一项前瞻性横断面研究，随机选择 100 个 PTNB，50 个研究组（脓毒症）和 50 个对照组（非脓毒症）。采用的神经系统评估方案是 Hammersmith 新生儿神经系统检查 (HNNE)。

结果

在 86% 的病例中，脓毒症组的 PTNB 总 HNNE 得分低于正常预期，非脓毒症组为 26% ( p < .001)。在音调类别 ( p < .001)、音调模式 ( p = .026)、反射 ( p = .002)、运动 ( p < .001)、异常体征 ( p < .001) 和行为 ( p < .001)。

结论

新生儿脓毒症后的神经功能障碍可以通过临床新生儿神经学评估来确定。