Iron chelation suppresses secondary bleeding after intracerebral hemorrhage in angiotensin II-infused mice,CNS Neuroscience & Therapeutics

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Iron chelation suppresses secondary bleeding after intracerebral hemorrhage in angiotensin II-infused mice
CNS Neuroscience & Therapeutics ( IF 4.8 ) Pub Date : 2021-08-04 , DOI: 10.1111/cns.13706
Jie Wang _{1,

2,

3} , Xiao-Qin Tang ₁ , Min Xia ₁ , Cheng-Cheng Li ₁ , Chao Guo ₁ , Hong-Fei Ge ₁ , Yi Yin ₁ , Bo Wang ₁ , Wei-Xiang Chen ₁ , Hua Feng _{1,

2,

3}

Affiliation

Secondary bleeding and further hematoma expansion (HE) aggravate brain injury after intracerebral hemorrhage (ICH). The majority of HE results from hypertensive ICH. Previous study reported higher iron content in the brains of hypertensive patients. Iron overload exacerbates the risk of hemorrhagic transformation in thromboembolic stroke mice. Whether iron overload during the process of hypertension participates in secondary bleeding of hypertensive ICH remains unclear.

中文翻译：

铁螯合抑制血管紧张素 II 注入小鼠脑出血后的继发性出血

继发性出血和进一步的血肿扩大 (HE) 会加重脑出血 (ICH) 后的脑损伤。大多数 HE 是由高血压 ICH 引起的。先前的研究报告了高血压患者大脑中的铁含量较高。铁过载加剧了血栓栓塞性中风小鼠出血性转化的风险。高血压过程中铁超负荷是否参与高血压脑出血继发性出血尚不清楚。

更新日期：2021-10-11

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