当前位置: X-MOL 学术Expert Rev. Mol. Med. › 论文详情
Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)
COVID-19 pandemic: insights into molecular mechanisms leading to sex-based differences in patient outcomes
Expert Reviews in Molecular Medicine ( IF 4.5 ) Pub Date : 2021-08-03 , DOI: 10.1017/erm.2021.9
Ashutosh Kumar 1, 2 , Ravi K Narayan 1, 2 , Maheswari Kulandhasamy 1, 3 , Pranav Prasoon 1, 4 , Chiman Kumari 1, 5 , Sujeet Kumar 1, 6 , Vikas Pareek 1, 7 , Kishore Sesham 1, 8 , Prakash S Shekhawat 1, 9 , Kamla Kant 1, 10 , Santosh Kumar 1, 11
Affiliation  

Recent epidemiological studies analysing sex-disaggregated patient data of coronavirus disease 2019 (COVID-19) across the world revealed a distinct sex bias in the disease morbidity as well as the mortality – both being higher for the men. Similar antecedents have been known for the previous viral infections, including from coronaviruses, such as severe acute respiratory syndrome (SARS) and middle-east respiratory syndrome (MERS). A sound understanding of molecular mechanisms leading to the biological sex bias in the survival outcomes of the patients in relation to COVID-19 will act as an essential requisite for developing a sex-differentiated approach for therapeutic management of this disease. Recent studies which have explored molecular mechanism(s) behind sex-based differences in COVID-19 pathogenesis are scarce; however, existing evidence, for other respiratory viral infections, viz. SARS, MERS and influenza, provides important clues in this regard. In attempt to consolidate the available knowledge on this issue, we conducted a systematic review of the existing empirical knowledge and recent experimental studies following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The qualitative analysis of the collected data unravelled multiple molecular mechanisms, such as evolutionary and genetic/epigenetic factors, sex-linkage of viral host cell entry receptor and immune response genes, sex hormone and gut microbiome-mediated immune-modulation, as the possible key reasons for the sex-based differences in patient outcomes in COVID-19.

中文翻译:

COVID-19 大流行:深入了解导致患者结局性别差异的分子机制

最近的流行病学研究分析了全球 2019 年冠状病毒病 (COVID-19) 的按性别分列的患者数据,揭示了疾病发病率和死亡率的明显性别偏见——男性均较高。以前的病毒感染也有类似的前因,包括冠状病毒,如严重急性呼吸综合征 (SARS) 和中东呼吸综合征 (MERS)。对导致患者与 COVID-19 相关的生存结果中的生物性别偏见的分子机制有充分的了解,将成为开发一种针对这种疾病的治疗管理的性别差异化方法的必要条件。最近探索 COVID-19 发病机制中基于性别的差异背后的分子机制的研究很少;然而,现有的证据,对于其他呼吸道病毒感染,即。非典、中东呼吸综合征和流感,提供了这方面的重要线索。为了巩固关于这个问题的现有知识,我们按照系统评价和元分析的首选报告项目 (PRISMA) 指南对现有的经验知识和最近的实验研究进行了系统评价。对收集数据的定性分析揭示了多种分子机制,如进化和遗传/表观遗传因素、病毒宿主细胞进入受体和免疫反应基因的性连锁、性激素和肠道微生物组介导的免疫调节,可能是关键COVID-19 患者结局性别差异的原因。为了巩固关于这个问题的现有知识,我们按照系统评价和元分析的首选报告项目 (PRISMA) 指南对现有的经验知识和最近的实验研究进行了系统评价。对收集数据的定性分析揭示了多种分子机制,如进化和遗传/表观遗传因素、病毒宿主细胞进入受体和免疫反应基因的性连锁、性激素和肠道微生物组介导的免疫调节,可能是关键COVID-19 患者结局性别差异的原因。为了巩固关于这个问题的现有知识,我们按照系统评价和元分析的首选报告项目 (PRISMA) 指南对现有的经验知识和最近的实验研究进行了系统评价。对收集数据的定性分析揭示了多种分子机制,如进化和遗传/表观遗传因素、病毒宿主细胞进入受体和免疫反应基因的性连锁、性激素和肠道微生物组介导的免疫调节,可能是关键COVID-19 患者结局性别差异的原因。我们按照系统评价和元分析 (PRISMA) 指南的首选报告项目对现有的经验知识和最近的实验研究进行了系统评价。对收集数据的定性分析揭示了多种分子机制,如进化和遗传/表观遗传因素、病毒宿主细胞进入受体和免疫反应基因的性连锁、性激素和肠道微生物组介导的免疫调节,可能是关键COVID-19 患者结局性别差异的原因。我们按照系统评价和元分析 (PRISMA) 指南的首选报告项目对现有的经验知识和最近的实验研究进行了系统评价。对收集数据的定性分析揭示了多种分子机制,如进化和遗传/表观遗传因素、病毒宿主细胞进入受体和免疫反应基因的性连锁、性激素和肠道微生物组介导的免疫调节,可能是关键COVID-19 患者结局性别差异的原因。
更新日期:2021-08-03
down
wechat
bug