Triglyceride-rich lipoproteins deliver fatty acids to tissues for oxidation and for storage. Release of fatty acids from circulating lipoprotein triglycerides is carried out by lipoprotein lipase (LPL), thus LPL serves as a critical gatekeeper of fatty acid uptake into tissues. LPL activity is regulated by a number of extracellular proteins including three members of the angiopoietin-like family of proteins. In this review we discuss our current understanding of how, where, and when ANGPTL3, ANGPTL4, and ANGPTL8 regulate lipoprotein lipase activity, with a particular emphasis on how these proteins interact with each other to coordinate triglyceride metabolism and fat partitioning.

中文翻译：

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ANGPTL3、ANGPTL4 和 ANGPTL8 对脂蛋白代谢的调节

富含甘油三酯的脂蛋白将脂肪酸输送到组织进行氧化和储存。从循环脂蛋白甘油三酯中释放脂肪酸是由脂蛋白脂肪酶 (LPL) 进行的，因此 LPL 是脂肪酸摄取到组织中的关键看门人。LPL 活性受许多细胞外蛋白的调节，包括血管生成素样蛋白家族的三个成员。在这篇综述中，我们讨论了我们目前对 ANGPTL3、ANGPTL4 和 ANGPTL8 调节脂蛋白脂肪酶活性的方式、地点和时间的理解，特别强调这些蛋白质如何相互作用以协调甘油三酯代谢和脂肪分配。