Coumarin derivatives are essential scaffolds in medicinal and synthetic chemistry. Compounds of this class have shown important activities, such as anticancer and antiparasitic, besides the commercially available drugs. These properties led to the development of efficient and greener synthetic methods to achieve the 2H-chromen-2-one core. In this context, the advances in asymmetric organocatalyzed synthesis of coumarin derivatives are discussed in this review, according to the mode of activation of the catalyst.

中文翻译：

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香豆素衍生物的不对称有机催化合成


香豆素衍生物是药物和合成化学中重要的支架。除市售药物外，此类化合物还显示出重要的活性，例如抗癌和抗寄生虫。这些特性促进了高效、更环保的合成方法的开发，以实现 2 H -chromen-2-one 核心。在此背景下，本文根据催化剂的活化模式，讨论了香豆素衍生物的不对称有机催化合成的进展。