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Developing centrifugal spun thermally cross-linked gelatin based fibrous biomats for antibacterial wound dressing applications
Polymer Engineering and Science ( IF 3.2 ) Pub Date : 2021-08-03 , DOI: 10.1002/pen.25759 Melike Gungor 1 , Merve Nur Sagirli 1 , Mehmet Durmus Calisir 1, 2 , Sule Selcuk 1 , Ali Kilic 1, 3
Polymer Engineering and Science ( IF 3.2 ) Pub Date : 2021-08-03 , DOI: 10.1002/pen.25759 Melike Gungor 1 , Merve Nur Sagirli 1 , Mehmet Durmus Calisir 1, 2 , Sule Selcuk 1 , Ali Kilic 1, 3
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Fibrous materials obtained from natural polymers, such as gelatin, have been used in medical applications due to their biocompatibility and biodegradability. Herein, free-standing durable fibrous gelatin biomats with antibacterial activity were developed via a simple, low cost and fast production route, centrifugal spinning, and subsequent thermal crosslinking. After a series of preliminary experiments, droplet−/bead-free porous biomats with fine fibers, 3.41 ± 1.8 μm in diameter, were fabricated. Subsequently, antimicrobial biomats were produced by adding AgNO3 into the production solution. X-ray diffractometer and energy dispersive X-ray results showed Ag NPs existing as AgCl in the biomats, which could be attributed to chemical reaction between the Ag NPs and residual Cl in the impure gelatin. Later, both the neat-gelatin and Ag-gelatin biomats were thermally crosslinked at 170°C to gain stability against water. Although the Ag addition reduced ultimate tensile strength by half, from 881 to 495 kPa, the crosslinked biomats were robust enough to be used for wound dressing applications. They were also found to be highly breathable, with the air permeability of 256 and 81.2 mm/s, respectively. The biomats showed antibacterial activity against Escherichia coli and Staphylococcus aureus bacteria. The results show that the free-standing fibrous-gelatin-based biomats produced is applicable for wound dressing applications.
中文翻译：
开发离心纺丝热交联明胶基纤维生物垫，用于抗菌伤口敷料应用
从天然聚合物（如明胶）获得的纤维材料由于其生物相容性和生物降解性已被用于医疗应用。在此，通过简单、低成本和快速的生产路线、离心纺丝和随后的热交联，开发了具有抗菌活性的独立耐用纤维明胶生物垫。经过一系列初步实验，制造了直径为 3.41 ± 1.8 μm 的细纤维的无液滴/无珠多孔生物垫。随后，通过添加 AgNO 3生产抗菌生物垫进入生产解决方案。X 射线衍射仪和能量色散 X 射线结果表明，Ag NPs 以 AgCl 形式存在于生物垫中，这可能归因于 Ag NPs 与不纯明胶中残留的 Cl 之间的化学反应。后来，纯明胶和银明胶生物垫在 170°C 下热交联以获得对水的稳定性。尽管添加 Ag 将最终拉伸强度降低了一半，从 881 kPa 到 495 kPa，但交联生物垫足够坚固，可用于伤口敷料应用。还发现它们具有高度透气性，透气性分别为 256 和 81.2 毫米/秒。生物垫显示出对大肠杆菌和金黄色葡萄球菌的抗菌活性细菌。结果表明，生产的自立式纤维明胶基生物垫适用于伤口敷料应用。
更新日期：2021-09-06
中文翻译：
开发离心纺丝热交联明胶基纤维生物垫，用于抗菌伤口敷料应用
从天然聚合物（如明胶）获得的纤维材料由于其生物相容性和生物降解性已被用于医疗应用。在此，通过简单、低成本和快速的生产路线、离心纺丝和随后的热交联，开发了具有抗菌活性的独立耐用纤维明胶生物垫。经过一系列初步实验，制造了直径为 3.41 ± 1.8 μm 的细纤维的无液滴/无珠多孔生物垫。随后，通过添加 AgNO 3生产抗菌生物垫进入生产解决方案。X 射线衍射仪和能量色散 X 射线结果表明，Ag NPs 以 AgCl 形式存在于生物垫中，这可能归因于 Ag NPs 与不纯明胶中残留的 Cl 之间的化学反应。后来，纯明胶和银明胶生物垫在 170°C 下热交联以获得对水的稳定性。尽管添加 Ag 将最终拉伸强度降低了一半，从 881 kPa 到 495 kPa，但交联生物垫足够坚固，可用于伤口敷料应用。还发现它们具有高度透气性，透气性分别为 256 和 81.2 毫米/秒。生物垫显示出对大肠杆菌和金黄色葡萄球菌的抗菌活性细菌。结果表明，生产的自立式纤维明胶基生物垫适用于伤口敷料应用。
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