A humanized version of Foxp2 affects ultrasonic vocalization in adult female and male mice,Genes, Brain and Behavior

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A humanized version of Foxp2 affects ultrasonic vocalization in adult female and male mice
Genes, Brain and Behavior ( IF 2.4 ) Pub Date : 2021-08-02 , DOI: 10.1111/gbb.12764
Sophie von Merten _{1,

2} , Christine Pfeifle ₂ , Sven Künzel ₂ , Svenja Hoier ₂ , Diethard Tautz ₂

Affiliation

The transcription factor FoxP2 is involved in setting up the neuronal circuitry for vocal learning in mammals and birds and is thought to have played a special role in the evolution of human speech and language. It has been shown that an allele with a humanized version of the murine Foxp2 gene changes the ultrasonic vocalization of mouse pups compared to pups of the wild-type inbred strain. Here we tested if this humanized allele would also affect the ultrasonic vocalization of adult female and male mice. In a previous study, in which only male vocalization was considered and the mice were recorded under a restricted spatial and temporal regime, no difference in adult vocalization between genotypes was found. Here, we use a different test paradigm in which both female and male vocalizations are recorded in extended social contact. We found differences in temporal, spectral and syntactical parameters between the genotypes in both sexes, and between sexes. Mice carrying the humanized Foxp2 allele were using higher frequencies and more complex syllable types than mice of the corresponding wildtype inbred strain. Our results support the notion that the humanized Foxp2 allele has a differential effect on mouse ultrasonic vocalization. As mice carrying the humanized version of the Foxp2 gene show effects opposite to those of mice carrying disrupted or mutated alleles of this gene, we conclude that this mouse line represents an important model for the study of human speech and language evolution.

中文翻译：

Foxp2 的人性化版本影响成年雌性和雄性小鼠的超声波发声

转录因子FoxP2参与建立哺乳动物和鸟类声音学习的神经元回路，并被认为在人类言语和语言的进化中发挥了特殊作用。已经表明，具有鼠Foxp2人源化版本的等位基因与野生型近交系的幼鼠相比，基因改变了幼鼠的超声波发声。在这里，我们测试了这种人源化等位基因是否也会影响成年雌性和雄性小鼠的超声波发声。在之前的一项研究中，仅考虑雄性发声，并在受限的空间和时间状态下记录小鼠，但未发现基因型之间的成年发声存在差异。在这里，我们使用不同的测试范式，其中女性和男性的发声都记录在扩展的社会接触中。我们发现两性基因型之间以及两性之间的时间、光谱和句法参数存在差异。携带人源化Foxp2的小鼠等位基因比相应的野生型近交系小鼠使用更高的频率和更复杂的音节类型。我们的结果支持人源化Foxp2等位基因对小鼠超声发声有不同影响的观点。由于携带Foxp2基因的人源化版本的小鼠表现出与携带该基因的破坏或突变等位基因的小鼠相反的效果，我们得出结论，该小鼠系代表了研究人类言语和语言进化的重要模型。

更新日期：2021-09-14

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