A Novel Electrochemical Glassy Carbon Electrode Modified with Carbon Black and Glyceline Deep Eutectic Solvent within a Crosslinked Chitosan Film for Simultaneous Determination of Acetaminophen and Diclofenac,Electroanalysis

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A Novel Electrochemical Glassy Carbon Electrode Modified with Carbon Black and Glyceline Deep Eutectic Solvent within a Crosslinked Chitosan Film for Simultaneous Determination of Acetaminophen and Diclofenac
Electroanalysis ( IF 2.7 ) Pub Date : 2021-08-03 , DOI: 10.1002/elan.202100325
Gabriela Piton ₁ , Karen Kenlderi ₁ , Ademar Wong ₂ , Fernando Moraes ₁ , Orlando Fatibello-Filho ₁

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Glyceline, reline, or ethaline deep eutectic solvents and carbon black nanoparticles within a crosslinked chitosan film are investigated as glassy carbon electrode modifiers for the first time. The selected 5 mg mL⁻¹ glyceline modified GCE was characterized by cyclic voltammetry, electrochemical impedance spectroscopy, and scanning electron microscopy. Simultaneous determination of acetaminophen and diclofenac by differential pulse adsorptive stripping voltammetry (DPAdSV) presented limits of detection of 2.6×10⁻⁸ and 5.2×10⁻⁸ mol L⁻¹ for acetaminophen and diclofenac, respectively, in pharmaceutical and biological samples. The obtained results were compared with those obtained by HPLC at a confidence level of 95 %.

中文翻译：

一种在交联壳聚糖薄膜中用炭黑和甘氨酸深共熔溶剂改性的新型电化学玻碳电极，用于同时测定对乙酰氨基酚和双氯芬酸

首次研究了交联壳聚糖膜中的甘油、再衬里或乙胺醇深共熔溶剂和炭黑纳米粒子作为玻璃碳电极改性剂。所选的 5 mg mL ^-1甘油改性 GCE 通过循环伏安法、电化学阻抗谱和扫描电子显微镜进行表征。通过差分脉冲吸附溶出伏安法 (DPAdSV) 同时测定对乙酰氨基酚和双氯芬酸的检测限分别为 2.6×10 ^-8和 5.2×10 ^-8 mol L ^-1对乙酰氨基酚和双氯芬酸，在药物和生物样品中。将获得的结果与通过 HPLC 获得的结果进行比较，置信度为 95%。

更新日期：2021-08-03

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