Phospholipase C γ1 (PLCγ1) is a member of the PLC family that functions as signal transducer by hydrolyzing membrane lipid to generate second messengers. The unique protein structure of PLCγ1 confers a critical role as a direct effector of VEGFR2 and signaling mediated by other receptor tyrosine kinases. The distinct vascular phenotypes in PLCγ1-deficient animal models and the gain-of-function mutations of PLCγ1 found in human endothelial cancers point to a major physiological role of PLCγ1 in the endothelial system. In this review, we discuss aspects of physiological and molecular function centering around PLCγ1 in the context of endothelial cells and provide a perspective for future investigation.

磷脂酶 C γ1 (PLCγ1) 是 PLC 家族的一员，通过水解膜脂产生第二信使，发挥信号转导的作用。PLCγ1 独特的蛋白质结构赋予其作为 VEGFR2 的直接效应子和由其他受体酪氨酸激酶介导的信号传导的关键作用。PLCγ1缺陷动物模型中不同的血管表型和人内皮癌中发现的PLCγ1功能获得性突变表明PLCγ1在内皮系统中的主要生理作用。在这篇综述中，我们讨论了在内皮细胞背景下以 PLCγ1 为中心的生理和分子功能方面，并为未来的研究提供了一个视角。