Mitochondria, the organelles classically seen as the powerhouse of the cell, are increasingly associated with a wide variety of neurodevelopmental disorders. Although individually rare, a myriad of pediatric neurogenetic disorders have been identified in the last few years, thanks to advances in clinical genetic sequencing and data analysis. As this exponential growth continues, mitochondrial dysfunction is increasingly implicated in childhood neurodevelopmental disorders, with clinical presentations ranging from syndromic autism, intellectual disability, and epileptic encephalopathies to childhood onset neurodegeneration. Here we review recent evidence demonstrating mitochondrial involvement in neurodevelopmental disorders, identify emerging mechanistic trends, and reconsider the long-standing question of the role of mitochondria in light of new evidence: causation versus mere association.
Dev Neurosci

中文翻译：

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线粒体功能障碍：神经发育障碍的共同点？


线粒体是传统上被视为细胞动力源的细胞器，它与多种神经发育障碍的关系越来越密切。尽管个体罕见，但由于临床基因测序和数据分析的进步，过去几年已经发现了无数的儿科神经遗传性疾病。随着这种指数级增长的持续，线粒体功能障碍越来越多地与儿童神经发育障碍相关，其临床表现包括自闭症综合征、智力障碍、癫痫性脑病以及儿童期发病的神经变性。在这里，我们回顾了最近证明线粒体参与神经发育障碍的证据，确定了新出现的机制趋势，并根据新证据重新考虑线粒体作用的长期存在的问题：因果关系与单纯的关联。
 开发神经科学