Apathy is a neurobehavioral syndrome characterized by impaired motivation for goal-directed behaviors and cognitive activity, alongside blunted affect. Apathy is a common neuropsychiatric syndrome in Alzheimer’s disease (AD), with a 5-year prevalence over 70%. Apathy also serves as a prognostic indicator, correlating with the progression of AD. Despite advances in its conceptualization and understanding of its neural basis, there is very limited empirical evidence to support the available strategies for the treatment of apathy in AD. Given its complex pathophysiology, including distinct substrates for different apathy dimensions (affective, cognitive, and behavioral), it is unlikely that a single pharmacological or nonpharmacological strategy will be effective for all cases of apathy in AD. High-quality evidence research is needed to better understand the role of specific strategies aiming at a personalized approach.

中文翻译：

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重新审视阿尔茨海默病的冷漠：从概念化到治疗方法

冷漠是一种神经行为综合征，其特征是目标导向行为和认知活动的动机受损，以及情感迟钝。冷漠是阿尔茨海默病 (AD) 中常见的神经精神综合征，5 年患病率超过 70%。冷漠也可作为预后指标，与 AD 的进展相关。尽管在其概念化和对其神经基础的理解方面取得了进展，但支持治疗 AD 冷漠的可用策略的经验证据非常有限。鉴于其复杂的病理生理学，包括不同冷漠维度（情感、认知和行为）的不同底物，单一的药物或非药物策略不太可能对 AD 中的所有冷漠病例都有效。