Lipid metabolism is altered in the acidic tumor microenvironment. Here, the authors show that polyunsaturated fatty acid supplementation, together with concomitant inhibition of lipid droplet biogenesis, induces ferroptosis in acidic cancer cells. These findings highlight the potential to exploit cancer dependence on exogenous lipids as a therapeutic vulnerability.

中文翻译：

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以酸味结尾：脂质在癌症中协调铁死亡

酸性肿瘤微环境中的脂质代谢发生改变。在这里，作者表明，补充多不饱和脂肪酸，同时抑制脂滴的生物发生，可诱导酸性癌细胞发生铁死亡。这些发现突出了利用癌症对外源性脂质的依赖作为治疗脆弱性的潜力。