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CD36 pumps fat to defang killer T cells in tumors
Cell Metabolism ( IF 27.7 ) Pub Date : 2021-08-03 , DOI: 10.1016/j.cmet.2021.07.004
Manikandan Subramanian 1 , Federica M Marelli-Berg 1
Affiliation  

The tumor microenvironment is immunosuppressive. Here we preview two recent studies from Ma et al. (2021) in Cell Metabolism and Xu et al. (2021) in Immunity that describe a key role of T cell-expressed CD36 in enhancing lipid uptake and mediating lipid peroxidation that ultimately leads to CD8+ T cell dysfunction, ferroptosis, and reduced anti-tumor function.



中文翻译:

CD36 泵送脂肪以去除肿瘤中的杀伤性 T 细胞

肿瘤微环境是免疫抑制的。在这里,我们预览了 Ma 等人最近的两项研究。(2021)细胞代谢和 Xu 等人。(2021) 在Immunity中描述了 T 细胞表达的 CD36 在增强脂质摄取和介导脂质过氧化中的关键作用,最终导致 CD8+ T 细胞功能障碍、铁死亡和抗肿瘤功能降低。

更新日期:2021-08-03
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