Chirality in peptide-based materials: From chirality effects to potential applications,Chirality

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Chirality in peptide-based materials: From chirality effects to potential applications
Chirality ( IF 2.8 ) Pub Date : 2021-08-02 , DOI: 10.1002/chir.23344
Zhonghui Chen _{1,

2} , Zhenguo Chi ₁ , Yifeng Sun ₂ , Ziyu Lv ₃

Affiliation

Chirality is ubiquitous in nature with primary cellular functions that include construction of right-/left-handed helix and selective communications among diverse biomolecules. Of particularly intriguing are the chiral peptide-based materials that can be deliberately designed to change physicochemistry properties via tuning peptide sequences. Critically, understanding their chiral effects are fundamental for the development of novel materials in chemistry and biomedicine fields. Here, we review recent researches on chirality in peptide-based materials, summarizing relevant typical chiral effects towards recognition, amplification, and induction. Driven forces for the chiral discrimination in affinity interaction as well as the handedness preferences in supramolecular structure formation at both the macroscale and microscale are illustrated. The implementation of such chirality effects of artificial copolymers, assembled aggregates and their composites in the fields of bioseparation and bioenrichment, cell incubation, protein aggregation inhibitors, chiral smart gels, and bionic electro devices are also presented. At last, the challenges in these areas and possible directions are pointed out. The diversity of chiral roles in the origin of life and chirality design in different organic or composite systems as well as their applications in drug development and chirality detection in environmental protection are discussed.

中文翻译：

肽基材料中的手性：从手性效应到潜在应用

手性在自然界中无处不在，主要的细胞功能包括构建右旋/左旋螺旋和不同生物分子之间的选择性通讯。特别有趣的是基于手性肽的材料，可以通过调整肽序列来故意设计以改变物理化学性质。至关重要的是，了解它们的手性效应对于化学和生物医学领域新材料的开发至关重要。在这里，我们回顾了最近关于肽基材料手性的研究，总结了相关的典型手性效应对识别、放大和诱导的影响。说明了亲和相互作用中手性辨别的驱动力以及宏观和微观尺度上超分子结构形成中的手性偏好。还介绍了人工共聚物、组装聚集体及其复合材料在生物分离和生物富集、细胞培养、蛋白质聚集抑制剂、手性智能凝胶和仿生电子器件领域的这种手性效应的实现。最后指出了这些领域的挑战和可能的发展方向。讨论了不同有机或复合体系中手性作用在生命起源和手性设计中的多样性及其在药物开发和环保手性检测中的应用。最后指出了这些领域的挑战和可能的发展方向。讨论了不同有机或复合体系中手性作用在生命起源和手性设计中的多样性及其在药物开发和环保手性检测中的应用。

更新日期：2021-09-17

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