Pterostilbene suppresses oxidative stress and allergic airway inflammation through AMPK/Sirt1 and Nrf2/HO-1 pathways,Immunity, Inflammation and Disease

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Pterostilbene suppresses oxidative stress and allergic airway inflammation through AMPK/Sirt1 and Nrf2/HO-1 pathways
Immunity, Inflammation and Disease ( IF 2.493 ) Pub Date : 2021-08-02 , DOI: 10.1002/iid3.490
Chang Xu _{1,

2} , Yilan Song _{1,

2} , Zhiguang Wang _{1,

3} , Jingzhi Jiang _{1,

2} , Yihua Piao _{1,

4} , Li Li _{1,

2} , Shan Jin ₅ , Liangchang Li _{1,

2} , Lianhua Zhu ₅ , Guanghai Yan _{1,

2}

Affiliation

Pterostilbene (Pts) may be used for allergic asthma treatment. The AMPK/Sirt1 and Nrf2/HO-1 pathways are potential targets for asthma treatement. However, the relationship between Pts and AMPK/Sirt1 and Nrf2/HO-1 pathways in asthma is unclear. Herein, we aim to explore the pharmacological effects of Pts on oxidative stress and allergic inflammatory response as well as the mechanism involving AMPK/Sirt1 and Nrf2/HO-1 pathways.

中文翻译：

紫檀通过 AMPK/Sirt1 和 Nrf2/HO-1 通路抑制氧化应激和过敏性气道炎症

紫檀(Pts) 可用于治疗过敏性哮喘。AMPK/Sirt1 和 Nrf2/HO-1 通路是哮喘治疗的潜在目标。然而，哮喘中 Pts 与 AMPK/Sirt1 和 Nrf2/HO-1 通路之间的关系尚不清楚。在此，我们旨在探讨 Pts 对氧化应激和过敏性炎症反应的药理作用以及涉及 AMPK/Sirt1 和 Nrf2/HO-1 通路的机制。

更新日期：2021-08-02

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