Amyloid-β, metal ions, and reactive oxygen species are linked to the pathology of Alzheimer's disease (AD). To identify their roles in the pathology of AD and control their pathological reactivities, various chemical tools have been developed. The redox-based strategy for designing small molecules with multiple reactivities toward pathogenic factors has recently received significant attention. This Account briefly illustrates our current understanding of diverse pathological elements associated with AD and their redox properties. Furthermore, we summarize some examples of redox-active small molecules with multifunctionality that were constructed by tuning electronic properties through incorporating substituents onto the backbones.

中文翻译：

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阿尔茨海默病病理因素多重反应所必需的小分子的氧化还原特性

淀粉样蛋白-β、金属离子和活性氧与阿尔茨海默病 (AD) 的病理学有关。为了确定它们在 AD 病理学中的作用并控制它们的病理反应性，已经开发了各种化学工具。设计对致病因子具有多种反应性的小分子的基于氧化还原的策略最近受到了极大的关注。此帐户简要说明我们目前与AD和它们的氧化还原特性有关不同的病理因素的理解。此外，我们总结了一些具有多功能性的氧化还原活性小分子的例子，这些小分子是通过在主链上加入取代基来调整电子特性而构建的。