Exercise for individuals with bone metastases: A systematic review,Critical Reviews in Oncology/Hematology

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Exercise for individuals with bone metastases: A systematic review
Critical Reviews in Oncology/Hematology ( IF 5.5 ) Pub Date : 2021-08-03 , DOI: 10.1016/j.critrevonc.2021.103433
Sarah Weller ₁ , Nicolas H Hart ₂ , Kate A Bolam ₃ , Sami Mansfield ₄ , Daniel Santa Mina ₅ , Kerri M Winters-Stone ₆ , Anna Campbell ₇ , Friederike Rosenberger ₈ , Joachim Wiskemann ₈ , Morten Quist ₉ , Prue Cormie ₁₀ , Jennifer Goulart ₁₁ , Kristin L Campbell ₁₂

Affiliation

Provincial Programs, BC Cancer, 750 West Broadway, Vancouver, BC, V5Z 1H5, Canada.
Cancer and Palliative Care Outcomes Centre, Queensland University of Technology, 191 Ipswich Rd, Woolloongabba, QLD, 4102, Australia; Exercise Medicine Research Institute, Edith Cowan University, 270 Joondalup Drive, Joondalup, WA, 6027, Australia; Institute for Health Research, University of Notre Dame Australia, 23 High Street, Freemantle, WA, 6160, Australia.
Department of Neurobiology, Care Sciences and Society, Division of Nursing, Karolinska Institutet, Fack 23400, SE-141 83 Huddinge, Stockholm, Sweden.
Cancer Wellness for Life, 8022 Reeder Street, Lenexa, KS, 66214, USA.
Faculty of Kinesiology and Physical Education, University of Toronto, 27 King's College Cir, Toronto, Ontario, ON M5S, Canada.
Knight Cancer Institute, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd, Portland, OR, 97239, USA.
Department of Sport, Exercise and Health & Science, School of Applied Sciences, Edinburgh Napier University, Sighthill Court, Edinburgh, EH11 4BN, UK.
Department of Medical Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital, Im Neuenheimer Feld 460, Heidelberg, 69120, Germany.
The University Hospitals Centre for Health Research, Rigshospitalet, Blegdamsvej 9, 2100, København, Denmark.
Mary MacKillop Institute for Health Research, Australian Catholic University, 5/215 Spring Street, Melbourne, VIC, 3000, Australia.
Department of Radiation Oncology, BC Cancer, 2410 Lee Avenue, Victoria, BC, V8R 6V5, Canada.
Department of Physical Therapy, 212-2177 Wesbrook Mall, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.

Background

Exercise has the potential to improve physical function and quality of life in individuals with bone metastases but is often avoided due to safety concerns. This systematic review summarizes the safety, feasibility and efficacy of exercise in controlled trials that include individuals with bone metastases.

Methods

MEDLINE, Embase, Pubmed, CINAHL, PEDro and CENTRAL databases were searched to July 16, 2020.

Results

A total of 17 trials were included incorporating aerobic exercise, resistance exercise or soccer interventions. Few (n = 4, 0.5%) serious adverse events were attributed to exercise participation, with none related to bone metastases. Mixed efficacy results were found, with exercise eliciting positive changes or no change. The majority of trials included an element of supervised exercise instruction (n = 16, 94%) and were delivered by qualified exercise professionals (n = 13, 76%).

Conclusions

Exercise appears safe and feasible for individuals with bone metastases when it includes an element of supervised exercise instruction.

中文翻译：

骨转移患者的锻炼：系统评价

背景

锻炼有可能改善骨转移患者的身体机能和生活质量，但由于安全问题，经常被避免。本系统评价总结了在包括骨转移患者在内的对照试验中锻炼的安全性、可行性和有效性。

方法

检索了 MEDLINE、Embase、Pubmed、CINAHL、PEDro 和 CENTRAL 数据库至 2020 年 7 月 16 日。

结果

总共纳入了 17 项试验，包括有氧运动、阻力运动或足球干预。很少（n = 4, 0.5%）严重不良事件归因于运动参与，与骨转移无关。发现了混合的功效结果，运动引起积极变化或没有变化。大多数试验包括有监督的运动指导元素（n = 16, 94%），并且由合格的运动专业人员进行（n = 13, 76%）。