Introduction

Childhood head and neck cancers (HNC) are rare and represent a complex group of anatomical topographies. The aim of this study is to describe the distribution, the incidence and survival rates of children with malignant HNC in France.

Methods

A population-based study was conducted between 2000 and 2015 in children less than 15 years with a diagnosis of HNC using the French National Registry of Childhood Cancers database (RNCE). Age-standardized incidence rates (ASR) and survival analysis were performed.

Results

The 1623 included HNC represented 5.6% of all cancers included in the RNCE. The thyroid was the leading tumor site category (26.6%), followed by head and neck soft tissue location (15.4%) and the nasopharynx (10.8%). The most common cancers were thyroid gland carcinomas (26.1%), rhabdomyosarcomas (23.9%) and Burkitt Lymphomas (8.6%). Nasopharynx cancers and soft-tissue sarcomas were statistically more frequent in boys, while thyroid carcinomas were significantly more frequent in girls. The annual ASR was 8.6 new cancer cases per million children. For all HNC combined, the 5-year overall survival (OS) was 87.7% [95%CI: 85.9–89.2]. There was no statistically significant variation in 5-year OS between 2000-2007 and 2008–2015.

Conclusions

Epidemiological data on HNC distribution, incidence and survival contributes to better understand these tumors by quantifying their impact on the French population and assessing their burden. Regarding the exclusion of topographies and some histological origins performed by some authors, this report proposes new recommendations to study HNC in a pediatric population.

中文翻译：

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法国儿童头颈癌：2000 年至 2015 年的发病率、生存率和趋势

介绍

儿童头颈癌 (HNC) 很少见，代表了一组复杂的解剖学地形。本研究的目的是描述法国恶性 HNC 儿童的分布、发病率和存活率。

方法

2000 年至 2015 年间，使用法国国家儿童癌症登记数据库 (RNCE) 对诊断为 HNC 的 15 岁以下儿童进行了一项基于人群的研究。进行了年龄标准化发病率 (ASR) 和生存分析。

结果

包含的 1623 种 HNC 占 RNCE 中包含的所有癌症的 5.6%。甲状腺是主要的肿瘤部位类别 (26.6%)，其次是头颈部软组织位置 (15.4%) 和鼻咽 (10.8%)。最常见的癌症是甲状腺癌（26.1%）、横纹肌肉瘤（23.9%）和伯基特淋巴瘤（8.6%）。鼻咽癌和软组织肉瘤在男孩中的发病率更高，而甲状腺癌在女孩中的发病率明显更高。每年的 ASR 为每百万儿童 8.6 例新癌症病例。对于所有 HNC，5 年总生存率 (OS) 为 87.7% [95% CI：85.9–89.2]。2000-2007 年和 2008-2015 年之间的 5 年 OS 没有统计学上的显着差异。

结论

关于 HNC 分布、发病率和存活率的流行病学数据有助于通过量化它们对法国人口的影响和评估它们的负担来更好地了解这些肿瘤。关于排除一些作者进行的拓扑结构和一些组织学起源，本报告提出了在儿科人群中研究 HNC 的新建议。