Native and oxidised lipoproteins negatively regulate the serum amyloid A-induced NLRP3 inflammasome activation in human macrophages,Clinical & Translational Immunology

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Native and oxidised lipoproteins negatively regulate the serum amyloid A-induced NLRP3 inflammasome activation in human macrophages
Clinical & Translational Immunology ( IF 5.8 ) Pub Date : 2021-08-03 , DOI: 10.1002/cti2.1323
Katariina Nurmi ₁ , Katri Niemi ₂ , Ilona Kareinen ₂ , Kristiina Silventoinen ₁ , Martina B Lorey _{1,

2} , Yan Chen ₁ , Vesa-Petteri Kouri ₁ , Jukka Parantainen ₁ , Timo Juutilainen ₃ , Katariina Öörni ₂ , Petri T Kovanen ₂ , Dan Nordström _{1,

4} , Sampsa Matikainen ₁ , Kari K Eklund _{1,

5,

6}

Affiliation

The NLRP3 inflammasome plays a key role in arterial wall inflammation. In this study, we elucidated the role of serum lipoproteins in the regulation of NLRP3 inflammasome activation by serum amyloid A (SAA) and other inflammasome activators.

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