Variants in the signal transducer and activator of transcription 4 (STAT4) gene have an important role in the incident of multiple autoimmune diseases including type 1 diabetes mellitus (T1D). It is a genetically related auto-immune disorder that resulted from T cell-mediated destruction of pancreatic cells that are in control for the production of insulin in the blood. The current study aimed to clarify the role of STAT4 (rs7574865) variant allelic and genotypic variations in the susceptibility to type 1 diabetes among Egyptians by using the real-time PCR. A total of 100 patients and 100 controls were genotyped for rs7574865, and the biochemical and anthropometric parameters were measured to show that type 1 diabetic patients had significantly higher levels of HbA1c and triglycerides compared to non-diabetic individuals (P < 0.05). And genetically, the T allele and GT genotype have a significant correlation with diabetes type 1. It was confirmed by this study that the rs7574865 T allele and GT genotype have a significant correlation with diabetes type 1 incidence among Egyptian patients.

中文翻译：

---

评估埃及患者中 rs7574865 STAT4 基因变异与 1 型糖尿病的关联

信号转导和转录激活因子 4 (STAT4) 基因的变体在包括 1 型糖尿病 (T1D) 在内的多种自身免疫性疾病的发生中具有重要作用。它是一种遗传相关的自身免疫性疾病，由 T 细胞介导的胰腺细胞破坏引起，这些细胞控制血液中胰岛素的产生。目前的研究旨在通过使用实时 PCR 阐明 STAT4 (rs7574865) 变异等位基因和基因型变异在埃及人 1 型糖尿病易感性中的作用。共对 100 名患者和 100 名对照者进行了 rs7574865 基因分型，并测量了生化和人体测量参数，结果显示 1 型糖尿病患者的 HbA1c 和甘油三酯水平显着高于非糖尿病患者（P < 0.05）。