Granulosa cell tumours (GCTs) are the most common type of bovine ovarian neoplasm. We describe the morphological and immunohistochemical features of GCTs (n = 26) and a thecoma (n = 1) using antibodies to cytokeratin AE1/AE3, vimentin, desmin, nectin-4, anti-Müllerian hormone (AMH), inhibin α, c-erbB-2 oncoprotein and proliferating cell nuclear antigen. The results indicate that, based on the expression similarity of AE1/AE3 and inhibin α, the macrofollicular growth pattern of GCTs derives from highly differentiated granulosa cells (GCs), the Graafian follicle or early atretic follicle. The trabecular growth pattern of GCTs is inferred to be derived from GCs of the atretic follicle in mature animals. AMH is a useful marker for diagnosing bovine sex cord-stromal tumours because it was expressed in all GCT cases and in the single case of thecoma.

颗粒细胞瘤 (GCT) 是最常见的牛卵巢肿瘤类型。我们使用细胞角蛋白 AE1/AE3、波形蛋白、结蛋白、nectin-4、抗苗勒管激素 (AMH)、抑制素 α、c -erbB-2 癌蛋白和增殖细胞核抗原。结果表明，基于 AE1/AE3 和抑制素 α 的表达相似性，GCTs 的大卵泡生长模式来源于高度分化的颗粒细胞 (GCs)、Graafian 卵泡或早期闭锁卵泡。推测 GCT 的小梁生长模式来源于成熟动物闭锁卵泡的 GC。AMH 是诊断牛性索间质肿瘤的有用标志物，因为它在所有 GCT 病例和单个昏迷病例中均有表达。