In the present paper, we propose a mechanistic mathematical model describing the process of drug release from a drug delivery system. This model takes various aspects of drug release into account, namely gradual penetration of the surrounding solution into the system, dissolution of solid drug particles embedded within, diffusion of the dissolved drug, dissolution of the carrier and its collapse. Modeling the various processes in a holistic physics-based approach allows us to describe, first, the phenomenon of a sudden “burst” of drug release after a few weeks and, second, the premature termination of the release, which can be observed on drug release curves, for example, these described in Macha et al. (Front Bioeng Biotechnol 7(37):1–14, 2019), Trang et al. (Mater Today Proc 17:836–845, 2019) or Tang et al. (Dalton Trans 39(18):4435–4439, 2010).

在本文中，我们提出了一个机械数学模型，描述了药物从给药系统中释放的过程。该模型考虑了药物释放的各个方面，即周围溶液逐渐渗透到系统中、嵌入其中的固体药物颗粒的溶解、溶解药物的扩散、载体的溶解及其坍塌。在基于物理的整体方法中对各种过程进行建模使我们能够描述，首先，几周后药物释放突然“爆发”的现象，其次，释放的提前终止，这可以在药物上观察到。释放曲线，例如，这些在 Macha 等人中描述。（Front Bioeng Biotechnol 7(37):1–14, 2019），Trang 等人。(Mater Today Proc 17:836–845, 2019) 或 Tang 等人。（道尔顿跨 39（18）：4435–4439，2010 年）。