Temporary In Situ Hydrogel Dressings for Colon Polypectomies,ACS Biomaterials Science & Engineering

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Temporary In Situ Hydrogel Dressings for Colon Polypectomies
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2021-08-03 , DOI: 10.1021/acsbiomaterials.1c00549
Katherine Cook ₁ , Nada Naguib ₁ , Courtney E Price ₂ , Stefan Katharios ₂ , Jack Kirsch ₁ , Kareen Cortes ₁ , Katherine Hohl ₁ , George A O'Toole ₂ , Mark W Grinstaff ₁

Affiliation

Currently, no dressings are utilized after removal of polyps during a colonoscopy rendering these tissue sites susceptible to bleeding, sepsis, and perfusion. We report the design specifications, synthesis, and ex vivo evaluation of in situ polymerized hydrogels as colon wound dressings post polypectomy. The hydrogels exhibited varied properties to include moduli between 100 and 16 000 Pa, dissolution times between 4 h to 7 days or longer, swelling up to 200%, and adhesion to colon tissue from 0.1 to 0.4 N/cm². The hydrogels displayed minimal cytotoxicity, prevented the migration/spread of bacteria, and exhibited rapid gelation, a requirement for application to the lumen of the colon via an endoscope. This work highlights the structure–property relationship of hydrogels prepared from N-hydroxysuccinimide functionalized PEG cross-linkers and hyperbranched polyethylenimines or 4-arm PEG-NH₂ star polymers, and their potential as colon wound dressings.

中文翻译：

用于结肠息肉切除术的临时原位水凝胶敷料

目前，在结肠镜检查期间切除息肉后不使用任何敷料，使这些组织部位容易出血、败血症和灌注。我们报告了原位聚合水凝胶作为息肉切除术后结肠伤口敷料的设计规范、合成和体外评估。水凝胶表现出不同的特性，包括 100 至 16 000 Pa 之间的模量、4 小时至 7 天或更长时间之间的溶解时间、高达 200% 的溶胀以及 0.1 至 0.4 N/cm ^{2对结肠组织的粘附}. 水凝胶表现出最小的细胞毒性，防止细菌的迁移/扩散，并表现出快速凝胶化，这是通过内窥镜应用于结肠腔的要求。这项工作强调了由N-羟基琥珀酰亚胺官能化 PEG 交联剂和超支化聚乙烯亚胺或 4 臂 PEG-NH ₂星形聚合物制备的水凝胶的结构-性能关系，以及它们作为结肠伤口敷料的潜力。

更新日期：2021-09-13

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