Considering the fact that new, safe and incorporable treatment alternatives to therapeutic prophylaxis for tungiasis are lacking and sometimes proving difficult, this present study evaluated the potentials of integrating control approach involving focal premise treatment using 5% emulsifiable concentrate of cypermethrin, and topical application of Piper guineense oil with personal protection.

Of the 90 houses selected, their floors were classified into paved rooms & unpaved verandas, paved verandas & unpaved rooms, paved rooms & verandas, and unpaved rooms & verandas, and tested for the presence of sand fleas using the sweeping and beating as well as soil collection and extraction by tullgren funnel method before fumigation. A total of 100 individuals partitioned into four groups of 25 individuals each were assigned 3%, 5%, 10% and 15% of P. guineense oil irrespective of stages of embedded fleas.

The mean of sand fleas decreased from 1.14, 0.07, 0.21, and 1.66 to 0.37, 0.02, 0.09 and 1.08 after two weeks of single spray compared to the untreated location (p < 0.001). Furthermore, the mean lesions of stage I reduced to 0 after 2 to 6 days of 3%, 5%, 10% and 15% ointment application, and stage II and III after 10 to 12 days of 10% and 15% application respectively. The difference between tungiasis stages and exposure time for P. guineense ointment was highly significant p = 0.007 and p = 0.0002.

Notable reduction in severity score of acute and chronic tungiasis was observed thus indicating effectiveness of the topical ointment. Hexanolic oil extracts of P. guineense in 10% and 15% concentration would kill embedded sand flea and ameliorate the sufferings in endemic settings.

考虑到目前缺乏新的、安全的、不可合并的治疗方法来替代治疗性苔藓病，而且有时证明很困难，本研究评估了整合控制方法的潜力，包括使用 5% 氯氰菊酯乳油和局部应用Piper具有个人防护功能的珍珠油。

在选定的 90 间房屋中，他们的地板被分为铺砌的房间和未铺砌的阳台、铺砌的阳台和未铺砌的房间、铺砌的房间和阳台、未铺砌的房间和阳台，并使用扫地、敲打和熏蒸前用 tullgren 漏斗法收集和提取土壤。总共 100 个人被分成四组，每组 25 个人，被分配了 3%、5%、10% 和 15% 的P. guineense油，而不管嵌入跳蚤的阶段如何。

与未处理的位置相比，在单次喷雾两周后，沙蚤的平均值从 1.14、0.07、0.21 和 1.66 下降到 0.37、0.02、0.09 和 1.08（p  < 0.001）。此外，在施用 3%、5%、10% 和 15% 的软膏 2 至 6 天后，I 期的平均病变减少至 0，而在分别施用 10% 和 15% 的 10 至 12 天后，II 期和 III 期的平均病变减少到 0。P. guineense软膏的tungiasis 阶段和暴露时间之间的差异非常显着p  = 0.007 和p  = 0.0002。

观察到急性和慢性苔藓病的严重程度评分显着降低，从而表明外用软膏的有效性。10% 和 15% 浓度的P. guineense己醇油提取物可以杀死嵌入的沙蚤并减轻流行环境中的痛苦。