Objective: Fear of cancer recurrence (FCR) is a significant concern for family caregivers of cancer survivors and is associated with many adverse outcomes, including increased emotional distress and poorer quality of life. Although several theoretical models have been proposed to account for FCR in cancer survivors, their applicability to caregivers is unknown. The aim of this review was to identify clinical, demographic and psychological factors that are associated with, and predict, FCR in caregivers of cancer survivors. Method: AMED, CINAHL, Medline, PsycINFO, and Scopus were systematically searched for relevant studies reporting quantitative data on factors associated with FCR or similar constructs (e.g., worry or anxiety about cancer recurrence) in family caregivers of adult cancer survivors. Included studies were assessed for methodological quality using a standardized checklist adapted from the Agency for Healthcare Research and Quality. Results: Sixteen studies, half of which were cross-sectional, were included and summarized narratively. Non-modifiable factors, including age (n = 6) and treatment modality (n = 4), were found to be associated with increased FCR. Significant positive associations were also reported between illness perceptions and FCR (n = 3). However, there was heterogeneity across included studies with regards to factors examined and most were conducted in the USA. There were also several methodological limitations to the included studies. Conclusions: Research examining FCR in caregivers of cancer survivors has predominantly focused on demographic and clinical factors. Given the paucity of research exploring the psychological mechanisms underpinning FCR, future research should investigate theoretical underpinnings of FCR in caregivers of cancer survivors to support the development of psychological interventions for this population. Systematic Review Registration: PROSPERO, identifier [CRD42019119729].

中文翻译：

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癌症幸存者的家庭照顾者担心癌症复发的相关因素：系统评价。

目的：对癌症复发的恐惧 (FCR) 是癌症幸存者的家庭照顾者的一个重要问题，并且与许多不良后果有关，包括情绪困扰增加和生活质量下降。尽管已经提出了几种理论模型来解释癌症幸存者的 FCR，但它们对护理人员的适用性尚不清楚。本综述的目的是确定与癌症幸存者的照顾者的 FCR 相关并预测 FCR 的临床、人口统计学和心理因素。方法：系统地搜索了 AMED、CINAHL、Medline、PsycINFO 和 Scopus，以获取报告成年癌症幸存者的家庭照顾者的 FCR 或类似结构（例如，对癌症复发的担忧或焦虑）相关因素的定量数据的相关研究。使用来自医疗保健研究和质量机构的标准化检查表评估纳入研究的方法学质量。结果：纳入了 16 项研究，其中一半是横断面研究，并进行了叙述性总结。发现不可改变的因素，包括年龄 (n = 6) 和治疗方式 (n = 4)，与 FCR 增加有关。疾病认知和 FCR 之间也报告了显着的正相关（n = 3）。然而，纳入的研究在所检查的因素方面存在异质性，并且大多数研究在美国进行。纳入的研究也存在一些方法学上的局限性。结论：检查癌症幸存者照顾者 FCR 的研究主要集中在人口统计学和临床​​因素上。鉴于探索支持 FCR 的心理机制的研究很少，未来的研究应该调查 FCR 在癌症幸存者的照顾者中的理论基础，以支持针对该人群的心理干预的发展。系统审查注册：PROSPERO，标识符 [CRD42019119729]。