After ischemic stroke, microglia will be activated and play a key role in neuroinflammation and the destruction of the blood-brain barrier (BBB), and activated microglia could polarize into pro-inflammation M1 phenotype and anti-inflammation M2 phenotype. Dimethyl malonate (DMM) could reduce reactive oxygen species and we speculate DMM could regulate microglia to protect ischemic brain.

中文翻译：

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丙二酸二甲酯对缺血性中风后神经炎症和血脑屏障的保护作用。


缺血性中风后，小胶质细胞会被激活，在神经炎症和血脑屏障（BBB）的破坏中发挥关键作用，激活的小胶质细胞可极化为促炎M1表型和抗炎M2表型。丙二酸二甲酯 (DMM) 可以减少活性氧，我们推测 DMM 可以调节小胶质细胞以保护缺血的大脑。