Prevalence of Microscopic Colitis in Diarrhea-predominant Irittable Bowel Syndrome Patients: Cohort Study From Upper Egypt,Journal of Clinical Gastroenterology

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Prevalence of Microscopic Colitis in Diarrhea-predominant Irittable Bowel Syndrome Patients: Cohort Study From Upper Egypt
Journal of Clinical Gastroenterology ( IF 2.8 ) Pub Date : 2022-03-01 , DOI: 10.1097/mcg.0000000000001592
Basel Ebeid ₁ , Ragaey A Eid ₁ , Dina Attia ₁ , Sahar A Daoud ₂ , Mohammad M Tawfik ₁ , Ali M Abdel Fattah ₁

Affiliation

Background and Aim:

There is controversy about colonoscopy and taking biopsy from the normal colonic mucosa in patients with a clinical diagnosis of diarrhea-predominant irritable bowel syndrome (D-IBS). This study aims to estimate the prevalence of microscopic colitis (MC) in D-IBS patients and to select patients without the well-known alarming features who will benefit from colonoscopy and biopsies from the normal colonic mucosa.

Patients and Methods:

We performed a cohort cross-sectional study over 6 months duration in a total of 129 patients with Rome III criteria of D-IBS after excluding cases with features of organic diseases. Cases were subjected to colonoscopy and biopsies from the colonic mucosa that seemed normal.

Results:

Histopathologic examination of biopsies taken from cases with normal colonic mucosa revealed 86 (71.66%) cases with nonspecific colitis, 26 (21.66%) cases with MC and 8 (6.66%) cases with ulcerative colitis. Concomitant immunologic diseases (P=0.00005) and triggering drugs intake (P=0.006) were significantly more common in the MC group. The mean duration of diarrhea in MC patients was significantly longer than that of nonspecific colitis and ulcerative colitis patients (P=0.0006).

Conclusions:

Prevalence of MC in D-IBS patients from Upper Egypt is relatively high (21.66%). Concomitant immunologic diseases, possible triggering drugs intake, and long duration of diarrhea are significant risk factors for undiagnosed MC in D-IBS patients.

中文翻译：

腹泻为主的肠易激综合征患者中显微镜下结肠炎的患病率：来自上埃及的队列研究

背景和目标：

对于临床诊断为腹泻型肠易激综合征 (D-IBS) 的患者进行结肠镜检查和从正常结肠粘膜中进行活检存在争议。本研究旨在估计D-IBS 患者中微小结肠炎(MC) 的患病率，并选择没有众所周知的令人担忧特征的患者，这些患者将受益于结肠镜检查和正常结肠粘膜活检。

患者和方法：

我们在排除具有器质性疾病特征的病例后，对总共 129 名符合罗马 III 标准的 D-IBS 患者进行了一项为期 6 个月的队列横断面研究。对病例进行结肠镜检查和结肠粘膜活检，结果显示正常。

结果：

对正常结肠粘膜病例进行组织病理学检查，发现非特异性结肠炎 86 例（71.66%），MC 26 例（21.66%），溃疡性结肠炎 8 例（6.66%）。MC 组中伴随免疫疾病 ( P = 0.00005) 和触发药物摄入 ( P = 0.006) 明显更常见。MC患者的平均腹泻持续时间显着长于非特异性结肠炎和溃疡性结肠炎患者（P =0.0006）。