Autoantibodies against proteins encoded by human endogenous retrovirus K (HERV-K) have been reported in patients with rheumatoid arthritis (RA), but their relevance, if any, has remained unresolved. We revisited this question and tested if such autoantibodies may react with citrullinated epitopes on the envelope (Env) protein of HERV-K.

中文翻译：

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类风湿性关节炎患者针对未修饰和瓜氨酸化人内源性逆转录病毒 K 包膜蛋白的自身抗体。

据报道，类风湿性关节炎 (RA) 患者会产生针对人内源性逆转录病毒 K (HERV-K) 编码蛋白的自身抗体，但它们的相关性（如果有的话）仍未得到解决。我们重新审视了这个问题并测试了此类自身抗体是否可能与 HERV-K 包膜 (Env) 蛋白上的瓜氨酸化表位发生反应。