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Liquid-liquid phase separation and self-assembly of a lysine derivative Fmoc-L-lysine in water-DMSO mixtures
Polymer Journal ( IF 2.3 ) Pub Date : 2021-08-02 , DOI: 10.1038/s41428-021-00538-3
Nikesh Narang 1 , Takahiro Sato 1
Affiliation  

The self-assembly process of a lysine derivative (9-fluorenylmethyloxycarbonyl-l-lysine; Fmoc-Lys) in water-DMSO mixtures was investigated by time-resolved static and dynamic light scattering (SLS and DLS), small-angle X-ray scattering (SAXS), optical microscopy (OM), and scanning electron microscopy (SEM). SLS, DLS, and SAXS indicated liquid–liquid phase separation caused by the addition of water to the DMSO solution of Fmoc-Lys and the formation of spherical droplets of the phase-separating concentrated phase with concentrations as high as 0.6 g/cm3. However, in the colloidal phase-separating solution, the concentrated phase droplets did not grow through the Ostwald ripening process, but OM and SEM implied that a crystal phase of Fmoc-Lys appeared after a long lag phase in the phase-separating solution. This crystallization process for Fmoc-Lys after liquid–liquid phase separation in DMSO-water mixtures has been reproduced semiquantitatively by lattice theory.



中文翻译:

赖氨酸衍生物 Fmoc-L-赖氨酸在水-DMSO 混合物中的液-液相分离和自组装

通过时间分辨静态和动态光散射(SLS 和 DLS)、小角度 X 射线研究了赖氨酸衍生物(9-芴基甲氧羰基-l-赖氨酸;Fmoc-Lys)在水-DMSO 混合物中的自组装过程散射 (SAXS)、光学显微镜 (OM) 和扫描电子显微镜 (SEM)。SLS、DLS 和 SAXS 表明在 Fmoc-Lys 的 DMSO 溶液中加入水引起液-液相分离,并形成浓度高达 0.6 g/cm 3的相分离浓缩相的球形液滴. 然而,在胶体相分离溶液中,浓相液滴没有通过 Ostwald 熟化过程生长,但 OM 和 SEM 表明 Fmoc-Lys 晶相在相分离溶液中经过长时间的滞后期后出现。在 DMSO-水混合物中液-液相分离后 Fmoc-Lys 的这种结晶过程已通过晶格理论半定量重现。

更新日期:2021-08-02
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