Elabela (ELA; also called Apela and Toddler) is one of the recently discovered ligand among the two endogenous peptide ligands (Apelin and Elabela) of the apelin receptor (APLNR, also known as APJ). Elabela-induced signaling plays a crucial role in diverse biological processes, including formation of the embryonic cardiovascular system and early placental development by reducing the chances of occurrence of preeclampsia during pregnancy. It also plays the major role in the renoprotection by reducing kidney injury and the inflammatory response and regulation of gene expression associated with heart failure and fibrosis. Elabela may be processed into different active peptides, each of which binds to APLNR and predominantly activates the signals through PI3K/AKT pathway. Owing to its biomedical importance, we developed a consolidated signaling map of Elabela, in accordance with the NetPath criteria. The presented Elabela signaling map comprises 12 activation/inhibition events, 15 catalysis events, 1 molecular association, 34 gene regulation events and 32 protein expression events. The Elabela signaling pathway map is freely made available through the WikiPathways Database (https://www.wikipathways.org/index.php/Pathway:WP5100).

Elabela（ELA；也称为 Apela 和 Toddler）是最近发现的 Apelin 受体（APLNR，也称为 APJ）的两种内源性肽配体（Apelin 和 Elabela）中的一种配体。Elabela 诱导的信号传导在多种生物过程中发挥着至关重要的作用，包括通过减少怀孕期间发生先兆子痫的机会来形成胚胎心血管系统和早期胎盘发育。它还通过减少肾损伤和炎症反应以及调节与心力衰竭和纤维化相关的基因表达，在肾脏保护中发挥重要作用。Elabela 可以加工成不同的活性肽，每一种都与 APLNR 结合并主要通过 PI3K/AKT 途径激活信号。由于其在生物医学上的重要性，我们根据 NetPath 标准开发了 Elabela 的综合信号图。呈现的 Elabela 信号图包括 12 个激活/抑制事件、15 个催化事件、1 个分子关联、34 个基因调控事件和 32 个蛋白质表达事件。Elabela 信号通路图可通过 WikiPathways 数据库 (https://www.wikipathways.org/index.php/Pathway:WP5100) 免费获得。