The aim of this work was to study the association of potential biomarkers with fast aortic stenosis (AS) progression. Patients with moderate-to-severe AS were classified as very fast progressors (VFP) if exhibited an annualized change in peak velocity (aΔVmax) ≥0.45m/s/year and/or in aortic valve area (aΔAVA) ≥−0.2cm2/year. Respective cut-off values of ≥0.3m/s/year and ≥−0.1cm²/year defined fast progressors (FP), whereas the remaining patients were non-fast progressors (non-FP). Baseline markers of lipid metabolism, inflammation, and cardiac overload were determined. Two hundred and nine patients (97 non-FP, 38 FP, and 74 VFP) were included. PCSK9 levels were significantly associated with VFP (OR 1.014 [95%CI 1.005-1.024], for every 10 ng/mL), as were active smoking (OR 3.48) and body mass index (BMI, OR 1.09), with an AUC of 0.704 for the model. PCSK9 levels, active smoking, and BMI were associated with very fast AS progression in our series, suggesting that inflammation and calcification participate in disease progression.

这项工作的目的是研究潜在的生物标志物与快速主动脉瓣狭窄 (AS) 进展的关系。如果峰值流速 (aΔVmax) ≥0.45m/s/年和/或主动脉瓣面积 (aΔAVA) ≥-0.2cm2/年变化，则中度至重度 AS 患者被归类为极快速进展者 (VFP)年。^{分别≥0.3m/s/年和≥−0.1cm 2}的截止值/年定义为快速进展者（FP），而其余患者为非快速进展者（非FP）。确定了脂质代谢、炎症和心脏超负荷的基线标志物。包括 209 名患者（97 名非 FP、38 名 FP 和 74 名 VFP）。PCSK9 水平与 VFP 显着相关（OR 1.014 [95%CI 1.005-1.024]，每 10 ng/mL），主动吸烟（OR 3.48）和体重指数（BMI，OR 1.09），AUC 为模型为 0.704。在我们的系列中，PCSK9 水平、主动吸烟和 BMI 与非常快的 AS 进展相关，这表明炎症和钙化参与了疾病进展。