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Domino Reaction Encoded Heterogeneous Colloidal Microswarm with On-Demand Morphological Adaptability
Advanced Materials ( IF 27.4 ) Pub Date : 2021-08-01 , DOI: 10.1002/adma.202100070
Dongdong Jin 1 , Ke Yuan 2 , Xingzhou Du 2 , Qianqian Wang 1 , Shijie Wang 1 , Li Zhang 1, 2, 3, 4
Affiliation  

Emulating natural swarm intelligence with group-level functionality in artificial micro/nanorobotic systems offers an opportunity to sublimate the limited functions of individuals and revolutionize their applications. However, achieving synchronous operation of microswarms with environmental adaptability and cooperative tasking capability remains a challenge. Here, an adaptive and heterogeneous colloidal magnetic microswarm with domino reaction encoded cooperative functions is presented. Through programming external magnetic fields, the system self-organizes into two swarm states, that is, vortex and ribbon microswarms, which can switch between each other reversibly within seconds, allowing to traverse tortuous, branched, and confined environments through adaptive morphological transformation. By specializing subgroups of building blocks with separate functions, cooperative tasking capability is integrated into the heterogeneous system following a “division of labor” manner. Given targeted therapy as a proof-of-concept task, the coordinated delivery of heterogeneous colloidal system across a complex environment with an access rate higher than 90% is demonstrated, and the specialization and cooperation between building blocks to disrupt multiple growth pathways of cancer cells via domino reaction are realized. The reconfigurable microswarm with hierarchical functionality presents a bioinspired approach to adapt to environmental variations and address multitasking requirements, which advances the development of microrobotic swarms and promises major benefits in biomedical fields.

中文翻译:

具有按需形态适应性的多米诺反应编码异质胶体微群

在人工微/纳米机器人系统中模拟具有群体级功能的自然群体智能提供了升华个人有限功能并彻底改变其应用的机会。然而,实现具有环境适应性和协作任务能力的微群同步运行仍然是一个挑战。在这里,提出了具有多米诺反应编码协作功能的自适应和异质胶体磁性微群。通过对外部磁场进行编程,该系统自组织成两种群体状态,即涡旋和带状微群,它们可以在几秒钟内可逆地相互切换,允许通过自适应形态变换穿越曲折、分支和受限的环境。通过专门化具有独立功能的积木子组,协作任务能力按照“分工”的方式集成到异构系统中。将靶向治疗作为概念验证任务,证明了异质胶体系统在复杂环境中的协调递送,访问率高于 90%,并且构建块之间的专业化和合作破坏了癌细胞的多种生长途径通过多米诺反应实现。具有分层功能的可重构微群提出了一种仿生方法来适应环境变化并满足多任务处理要求,这促进了微机器人群的发展,并有望在生物医学领域带来重大好处。协同任务能力按照“分工”的方式集成到异构系统中。将靶向治疗作为概念验证任务,证明了异质胶体系统在复杂环境中的协调递送,访问率高于 90%,并且构建块之间的专业化和合作破坏了癌细胞的多种生长途径通过多米诺反应实现。具有分层功能的可重构微群提出了一种仿生方法来适应环境变化并满足多任务处理要求,这促进了微机器人群的发展,并有望在生物医学领域带来重大好处。协同任务能力按照“分工”的方式集成到异构系统中。将靶向治疗作为概念验证任务,证明了异质胶体系统在复杂环境中的协调递送,访问率高于 90%,并且构建块之间的专业化和合作破坏了癌细胞的多种生长途径通过多米诺反应实现。具有分层功能的可重构微群提出了一种仿生方法来适应环境变化并满足多任务处理要求,这促进了微机器人群的发展,并有望在生物医学领域带来重大好处。证明了异质胶体系统在复杂环境中的协调传递,访问率高于 90%,并实现了构建块之间的专业化和协作,通过多米诺骨牌反应破坏癌细胞的多种生长途径。具有分层功能的可重构微群提出了一种仿生方法来适应环境变化并满足多任务处理要求,这促进了微机器人群的发展,并有望在生物医学领域带来重大好处。证明了异质胶体系统在复杂环境中的协调传递,访问率高于 90%,并实现了构建块之间的专业化和协作,通过多米诺骨牌反应破坏癌细胞的多种生长途径。具有分层功能的可重构微群提出了一种仿生方法来适应环境变化并满足多任务处理要求,这促进了微机器人群的发展,并有望在生物医学领域带来重大好处。
更新日期:2021-09-14
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