ABSTRACT

Big cities of Argentina are characterized by a strong social and economic fragmentation. This context enables the presence of urban rodents in close contact to the human population, mostly in the peripheral areas of the cities. Urban rodents can harbor a large variety of zoonotic pathogens. The aim of this study was to molecularly characterize Leptospira spp. and Bartonella spp. in urban rodents from the area of Gran La Plata, Buenos Aires province, Argentina. The species of urban rodents captured and tested were Rattus norvegicus, Rattus rattus, and Mus musculus. Leptospira interrogans and L. borgpetersenii were detected in R. norvegicus and M. musculus respectively. Bartonella spp. DNA was not detected in any of the kidney samples tested. No significant differences were observed between the prevalence of bacteria and rodent and environmental variables such as host sex, presence of stream and season by Generalized Linear Model analysis. These results confirm the role of urban rodents as infection sources of Leptospira spp., suggesting the need to implement public health measures to prevent the transmission of Leptospira spp. and other zoonotic pathogens from rodents to humans. Bartonella was not detected in this set of samples.

 抽象的

阿根廷大城市的特点是社会和经济严重分散。这种背景使得城市啮齿动物能够与人类密切接触，主要出现在城市的周边地区。城市啮齿动物可能携带多种人畜共患病原体。本研究的目的是对钩端螺旋体属进行分子表征。和巴尔通体属。来自阿根廷布宜诺斯艾利斯省格兰拉普拉塔地区的城市啮齿动物。捕获并测试的城市啮齿动物种类为褐家鼠、家鼠和小家鼠。分别在褐家鼠和小家鼠中检测到问号钩端螺旋体和博氏钩端螺旋体。巴尔通体属在所有测试的肾脏样本中均未检测到 DNA。通过广义线性模型分析，细菌和啮齿动物的流行率与宿主性别、河流存在和季节等环境变量之间没有观察到显着差异。这些结果证实了城市啮齿动物作为钩端螺旋体感染源的作用，表明需要采取公共卫生措施来预防钩端螺旋体的传播。以及从啮齿动物到人类的其他人畜共患病原体。这组样本中未检测到巴尔通体。