ABSTRACT

Background: The exaggerated morning blood pressure surge (MS) is associated with target organ damage and cardiovascular events. Systemic immune-inflammation index (SII) has been detected as a useful marker in tumors and cardiovascular diseases. The role of inflammation in the pathogenesis of hypertension is a well-known issue. We aimed to investigate whether there is an association between SII and exaggerated MS in newly diagnosed treatment-naive hypertensive patients.

Material and Methods: In total, 343 newly diagnosed in clinical and 24-h ambulatory blood pressure (BP) monitoring treatment-naive hypertensive patients were included in this study. Morning surge was defined as the difference between morning BP, which was the mean of BP during 2 h after wake-up, and the lowest BP, which was the mean of three lowest BP during nighttime. A cutoff value of 52.1 mmHg was used to discriminate the high- and low value MS groups. SII was calculated based on neutrophil, platelet, and lymphocyte counts.

Results: Neutrophil, platelet, SII, neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR) were higher, whereas lymphocyte counts were lower in the high-value MS than the low-value MS. These indices were all independently associated with exaggerated MS and SII was superior to all other indices for detecting the presence of exaggerated MS. SII was moderately correlated with morning BP surge (r: 0.489, p < 0.0001).

Conclusion: SII was higher in patients with exaggerated MS and was independently associated with exaggerated MS. Furthermore, SII might be a better indicator than platelet, neutrophil, lymphocyte, NLR, and PLR for the presence of exaggerated MS.

摘要

背景：夸张的早晨血压激增 (MS) 与靶器官损伤和心血管事件有关。全身免疫炎症指数 (SII) 已被检测为肿瘤和心血管疾病的有用标志物。炎症在高血压发病机制中的作用是一个众所周知的问题。我们的目的是调查新诊断的初治高血压患者的 SII 和夸大的 MS 之间是否存在关联。

材料和方法：本研究共纳入 343 名新诊断的临床和 24 小时动态血压 (BP) 监测初治高血压患者。晨峰定义为早晨血压（起床后 2 小时血压的平均值）与最低血压（夜间三个最低血压的平均值）之间的差值。52.1 mmHg 的临界值用于区分高值和低值 MS 组。根据中性粒细胞、血小板和淋巴细胞计数计算 SII。

结果：中性粒细胞、血小板、SII、中性粒细胞与淋巴细胞比率（NLR）、血小板与淋巴细胞比率（PLR）较高，而高值 MS 的淋巴细胞计数低于低值 MS。这些指标都与夸大的 MS 独立相关，并且 SII 优于所有其他指标，用于检测夸大 MS 的存在。SII 与早晨血压飙升呈中度相关（r：0.489，p < 0.0001）。

结论：夸大型 MS 患者的 SII 较高，并且与夸大型 MS 独立相关。此外，SII 可能是比血小板、中性粒细胞、淋巴细胞、NLR 和 PLR 更好的指示是否存在夸大 MS。