Bone metastasis occurs in about 70% of breast cancer patients. The surgical resection of metastatic tumors often leads to bone erosion and destruction, which greatly hinders the treatment and prognosis of breast cancer patients with bone metastasis. Herein, a bifunctional scaffold 3D-printed from nanoink is fabricated to simultaneously eliminate the tumor cells and repair the tumor-associated bone defects. The metallic polydopamine (PDA) nanoparticles (FeMg-NPs) may effectively load and sustainably release the metal ions Fe³⁺ and Mg²⁺ in situ. Fe³⁺ exerts a chemodynamic therapy to synergize with the photothermal therapy induced by PDA with effective photothermal conversion under NIR laser, which efficiently eliminates the bone-metastatic tumor. Meanwhile, the sustained release of osteoinductive Mg²⁺ from the bony porous 3D scaffold enhances the new bone formation in the bone defects. Taken together, the implantation of scaffold (FeMg-SC) 3D-printed from the FeMg-NPs-containing nanoink provides a novel strategy to simultaneously eradicate bone-metastatic tumor and repair the tumor-associated bone defects.

中文翻译：

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支架 3D 打印的金属纳米颗粒含有墨水，可同时根除肿瘤并修复与肿瘤相关的骨缺损

大约 70% 的乳腺癌患者发生骨转移。转移性肿瘤的手术切除往往会导致骨侵蚀和破坏，这极大地阻碍了乳腺癌骨转移患者的治疗和预后。在此，制造了一种由纳米墨水 3D 打印的双功能支架，以同时消除肿瘤细胞并修复与肿瘤相关的骨缺损。金属聚多巴胺（PDA）纳米粒子（FeMg-NPs）可以有效地负载并在原位持续释放金属离子Fe ³⁺和Mg ^{2+ 。}铁³⁺发挥化学动力学疗法与PDA诱导的光热疗法协同作用，在NIR激光下具有有效的光热转换，有效地消除了骨转移性肿瘤。^{同时，骨性多孔 3D 支架中骨诱导性 Mg 2+}的持续释放增强了骨缺损处的新骨形成。总之，植入由含有 FeMg-NPs 的纳米墨水 3D 打印的支架 (FeMg-SC) 提供了一种同时根除骨转移性肿瘤和修复肿瘤相关骨缺损的新策略。