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Investigation on the Stoichiometry of Carbon Dioxide in Isotope-Exchange Reactions with Phenylacetic Acids
Synlett ( IF 1.7 ) Pub Date : 2021-07-30 , DOI: 10.1055/s-0040-1720447
Davide Audisio , Alex Talbot , Antoine Sallustrau , Amélie Goudet , Frédéric Taran

The functionalization of carbon dioxide (CO2) as a C1 building block has attracted enormous attention. Carboxylation reactions, in particular, are of major interest for applications in isotope labeling. Due to the inexpensive nature of CO2, information about its stoichiometric use is generally unavailable in the literature. Because of the rarity and limited availability of CO2 isotopomers, this parameter is of concern for applications in carbon-isotope labeling. We investigated the effects of the stoichiometry of labeled CO2 on carbon isotope exchange of phenyl­acetic acids. Both thermal and photocatalytic procedures were studied, providing insight into product outcome and isotope incorporation. Preliminary results on isotope-dilution effects of carbonate bases in photocatalytic carboxylation reactions have also been obtained.



中文翻译:

与苯乙酸的同位素交换反应中二氧化碳的化学计量研究

二氧化碳 (CO 2 ) 作为 C1 构件的功能化引起了极大的关注。特别是羧化反应在同位素标记中的应用非常重要。由于 CO 2的廉价性质,文献中通常无法获得关于其化学计量用途的信息。由于 CO 2同位素异构体的稀有性和有限的可用性,该参数在碳同位素标记中的应用受到关注。我们研究了标记 CO 2的化学计量的影响苯乙酸的碳同位素交换。研究了热催化和光催化程序,提供了对产品结果和同位素掺入的深入了解。碳酸盐碱在光催化羧化反应中同位素稀释作用的初步结果也已获得。

更新日期:2021-08-02
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