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An automated system for fast transfer and injection of hyperpolarized solutions
Journal of Magnetic Resonance Open ( IF 1.5 ) Pub Date : 2021-08-01 , DOI: 10.1016/j.jmro.2021.100017
Morgan Ceillier 1 , Olivier Cala 1 , Théo El Daraï 1 , Samuel F. Cousin 1 , Quentin Stern 1 , Sylvie Guibert 1 , Stuart J. Elliott 1, 2 , Aurélien Bornet 3 , Basile Vuichoud 1 , Jonas Milani 3 , Christophe Pages 4 , Dmitry Eshchenko 5 , James G. Kempf 6 , Catherine Jose 4 , Simon A. Lambert 7 , Sami Jannin 1
Affiliation  

Dissolution dynamic nuclear polarization (dDNP) has become a hyperpolarization method of choice for enhancing nuclear magnetic resonance (NMR) signals. Nuclear spins are polarized in solid frozen samples (in a so-called polarizer) that are subsequently dissolved and transferred to an NMR spectrometer for high sensitivity detection. One of the critical challenges of dDNP is that it requires both a fast transfer to limit nuclear spin relaxation losses as well as stability to guarantee high resolution (no bubbles nor turbulences). Here we describe the design, construction and performances of such a transfer and injection system, that features a 5 m/s speed and sub-Hz spectral resolution upon arrival at the detection spot. We demonstrate the use of such a system for inter-magnet distances of up to 10 m.



中文翻译:

用于快速转移和注入超极化溶液的自动化系统

溶解动态核极化 ( d DNP) 已成为增强核磁共振 (NMR) 信号的首选超极化方法。核自旋在固体冷冻样品(在所谓的偏振器中)被极化,随后溶解并转移到 NMR 光谱仪进行高灵敏度检测。d的关键挑战之一DNP 既需要快速转移以限制核自旋弛豫损失,也需要稳定性以保证高分辨率(无气泡或湍流)。在这里,我们描述了这种传输和注入系统的设计、构造和性能,该系统在到达检测点时具有 5 m/s 的速度和亚赫兹的光谱分辨率。我们演示了使用这种系统来实现长达 10 m 的磁体间距离。

更新日期:2021-08-20
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