Background

Previous studies have shown that bipolar disorder (BD) patients frequently present with difficulties in interpersonal relationships, education or employment and suffer poorer quality of life. This study aimed to estimate the impact of BD on health-related quality of life (HRQOL), work productivity loss and indirect costs.

Methods

Data was from the online, self-administered 2019 National Health and Wellness Survey. Outcomes were compared for those who self-reported a physician diagnosis of BD (N=179), major depressive disorder (MDD, N=1,549) and controls who have never experienced BD, MDD and schizophrenia (N=27,485).

Results

The lifetime prevalence was estimated to be 0.60% for BD and 5.16% for MDD. Significantly lower Mental Component Summary (MCS), Role Component Summary (RCS) scores and EuroQol 5-dimension scale (EQ-5D-5L) summary index and significantly higher presenteeism, total work productivity impairment and activity impairment assessed by Work Productivity and Activity Impairment questionnaire and indirect costs for BD versus controls and BD PHQ-9≥10 versus PHQ-9<10 were observed. Compared to MDD patients, BD patients had significantly lower RCS score and greater work productivity loss and activity impairment. The national morbidity cost of BD in Japan was estimated to be Japanese yen 1,236 billion using a human-capital approach.

Limitations

The data used were self-reported and is cross-sectional in nature, thus causal relationship cannot be assumed.

Conclusion

BD patients and those with severe depressive symptoms experience significantly poorer HRQOL and greater work productivity loss and indirect costs. These findings highlight the importance of proper screening, diagnosis and treatment of BD and bipolar depression.

中文翻译：

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双相情感障碍对健康相关生活质量和工作效率的影响：来自日本全国健康调查的估计

背景

先前的研究表明，双相情感障碍 (BD) 患者经常在人际关系、教育或就业方面存在困难，并且生活质量较差。本研究旨在评估 BD 对健康相关生活质量 (HRQOL)、工作效率损失和间接成本的影响。

方法

数据来自在线自我管理的 2019 年全国健康与健康调查。比较那些自我报告被医生诊断为 BD（N=179）、重度抑郁症（MDD，N=1,549）的人和从未经历过 BD、MDD 和精神分裂症的对照者（N=27,485）的结果。

结果

BD 的终生患病率估计为 0.60%，MDD 为 5.16%。显着降低心理成分总结 (MCS)、角色成分总结 (RCS) 分数和 EuroQol 5 维量表 (EQ-5D-5L) 总结指数，显着提高出勤率、总工作效率受损和由工作生产力和活动受损评估的活动受损观察到 BD 与对照组和 BD PHQ-9≥10 与 PHQ-9<10 的问卷调查和间接成本。与 MDD 患者相比，BD 患者的 RCS 评分显着降低，工作效率损失和活动障碍更大。使用人力资本方法估计日本 BD 的全国发病成本为 12,360 亿日元。

限制

使用的数据是自我报告的，本质上是横断面的，因此不能假设因果关系。

结论

BD 患者和有严重抑郁症状的患者 HRQOL 明显更差，工作效率损失和间接成本更大。这些发现强调了正确筛查、诊断和治疗 BD 和双相抑郁症的重要性。