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Evaluation of radiophotoluminescent glass dosimeter response for therapeutic spot scanning proton beam: suggestion of linear energy transfer-based correction
Journal of Applied Clinical Medical Physics ( IF 2.0 ) Pub Date : 2021-08-02 , DOI: 10.1002/acm2.13378
Junya Nagata 1 , Keisuke Yasui 2 , Chihiro Omachi 3 , Toshito Toshiyuki 3 , Hidetoshi Shimizu 4 , Takahiro Aoyama 4 , Naoki Hayashi 2
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A radiophotoluminescent glass dosimeter (RGD) is used for a postal audit of a photon beam because of its various excellent characteristics. However, it has not been used for scanning proton beams because its response characteristics have not been verified. In this study, the response of RGD to scanning protons was investigated to develop a dosimetry protocol using the linear energy transfer (LET)-based correction factor. The responses of RGD to four maximum-range-energy-pattern proton beams were verified by comparing it with ionization chamber (IC) dosimetry. The LET at each measurement depth was calculated via Monte Carlo (MC) simulation. The LET correction factor (urn:x-wiley:15269914:media:acm213378:acm213378-math-0001) was the ratio between the uncorrected RGD dose (urn:x-wiley:15269914:media:acm213378:acm213378-math-0002) and the IC dose at each measurement depth. urn:x-wiley:15269914:media:acm213378:acm213378-math-0003 can be represented as a function of LET using the following equation: urn:x-wiley:15269914:media:acm213378:acm213378-math-0004. urn:x-wiley:15269914:media:acm213378:acm213378-math-0005 showed a linear under-response with increasing LET, and the maximum dose difference between the IC dose and urn:x-wiley:15269914:media:acm213378:acm213378-math-0006 was 15.2% at an LET of 6.07 keV/μm. The LET-based correction dose (urn:x-wiley:15269914:media:acm213378:acm213378-math-0007) conformed within 3.6% of the IC dose. The mean dose difference (±SD) of urn:x-wiley:15269914:media:acm213378:acm213378-math-0008 and urn:x-wiley:15269914:media:acm213378:acm213378-math-0009 was –2.5 ± 6.9% and 0.0 ± 1.6%, respectively. To achieve accurate dose verification for scanning proton beams using RGD, we derived a linear regression equation based on LET. The results show that with appropriate LET correction, RGD can be used for dose verification of scanning proton beams.

中文翻译:

放射光致发光玻璃剂量计对治疗性点扫描质子束响应的评估:基于线性能量转移的校正建议

辐射光致发光玻璃剂量计 (RGD) 因其各种优异的特性而被用于光子束的邮政审计。然而,它没有被用于扫描质子束,因为它的响应特性尚未得到验证。在这项研究中,研究了 RGD 对扫描质子的响应,以使用基于线性能量转移 (LET) 的校正因子开发剂量测定协议。通过将 RGD 与电离室 (IC) 剂量测定进行比较,验证了 RGD 对四个最大范围能量模式质子束的响应。每个测量深度的 LET 是通过蒙特卡罗 (MC) 模拟计算的。LET 校正因子 ( urn:x-wiley:15269914:media:acm213378:acm213378-math-0001) 是未校正 RGD 剂量 ( urn:x-wiley:15269914:media:acm213378:acm213378-math-0002) 与每个测量深度的 IC 剂量之比。骨灰盒:x-wiley:15269914:媒体:acm213378:acm213378-math-0003可以被表示为使用以下等式一个LET的功能:骨灰盒:x-wiley:15269914:媒体:acm213378:acm213378-math-0004骨灰盒:x-wiley:15269914:媒体:acm213378:acm213378-math-0005随着 LET 的增加,表现出线性反应不足,IC 剂量与骨灰盒:x-wiley:15269914:媒体:acm213378:acm213378-math-0006LET之间的最大剂量差异为 15.2%,LET 为 6.07 keV/μm。基于 LET 的校正剂量 ( urn:x-wiley:15269914:media:acm213378:acm213378-math-0007) 符合 IC 剂量的 3.6%。的平均剂量差(±SD)骨灰盒:x-wiley:15269914:媒体:acm213378:acm213378-math-0008骨灰盒:x-wiley:15269914:媒体:acm213378:acm213378-math-0009分别为-2.5±6.9%和0.0±1.6%。为了使用 RGD 实现扫描质子束的准确剂量验证,我们导出了基于 LET 的线性回归方程。结果表明,通过适当的 LET 校正,RGD 可用于扫描质子束的剂量验证。
更新日期:2021-08-15
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