Abstract

In the present research, a new coordination polymer with the chemical formula of [PrCl(HL)]_n (1) was synthesized by utilizing the pure chiral tricarboxyl ligand (S)-5-(((1-carboxy-2-phenylethyl)amino)methyl)isophthalic acid (H₃L). The important role of the new compound on prevention of hypotension after anesthesia and the bio-toxicity was evaluated, and at the same time, the relevant mechanism was also be investigated. The conclusive outcome of the present work from the molecular docking simulation identification is that the carboxyl and imino groups are interacting with the active sites on the alpha-2A-adrenergic receptor, which reveals the underlaying reason of the biological activity of the complex.

摘要

本研究利用纯手性三羧基配体( S )-5-(((1-羧基-2-苯乙基))合成了一种化学式为[PrCl(HL)] _n ( 1 )的新型配位聚合物。氨基）甲基）间苯二甲酸（H ₃ L）。评价了该新化合物对预防麻醉后低血压的重要作用及生物毒性，同时对其相关机制进行了探讨。本工作从分子对接模拟鉴定得出的结论性结果是羧基和亚氨基与α-2A-肾上腺素能受体上的活性位点相互作用，这揭示了复合物生物活性的潜在原因。