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Structural, optical, cytotoxic, and anti-microbial properties of amorphous silica nanoparticles synthesised via hybrid method for biomedical applications
Materials Technology ( IF 2.9 ) Pub Date : 2021-08-02 , DOI: 10.1080/10667857.2021.1959190
Shagun Varshney 1 , Abhishek Nigam 2 , S.J. Pawar 2 , Nidhi Mishra 1
Affiliation  

ABSTRACT

The present study reports a novel technique to synthesise silica nanoparticles through modified sol-gel, ultrasonication, and hydrothermal routes. Physio-chemical and structural characterization was carried out using X-ray diffraction, high resolution scanning electron microscopy, energy dispersive spectroscopy, dynamic light scattering, Fourier transform infrared spectroscopy, ultraviolet-visible, and photoluminescence spectroscopy. The particle size determination revealed the spherical structure of nanoparticles with an average diameter of 85 nm and between 90-170 nm through HRSEM and DLS respectively. Stretching and vibration bands confirming the presence of SiO2 were obtained in FTIR analysis. Spectra from UV-vis and PL spectroscopy were obtained at a maximum wavelength of 233 nm and 555 nm respectively. The anti-microbial effect of SiO2 nanoparticles against E. coli and S. aureus bacteria revealed the appreciable response which renders them for many biomedical applications like drug delivery. The cytotoxicity of SiO2 nanoparticles on human lung epithelial (A549) cell line revealed their non-toxic behavior.



中文翻译:

用于生物医学应用的混合方法合成的无定形二氧化硅纳米粒子的结构、光学、细胞毒性和抗菌性能

摘要

本研究报告了一种通过改性溶胶-凝胶、超声和水热途径​​合成二氧化硅纳米粒子的新技术。使用 X 射线衍射、高分辨率扫描电子显微镜、能量色散光谱、动态光散射、傅里叶变换红外光谱、紫外-可见光和光致发光光谱进行物理化学和结构表征。粒度测定分别通过HRSEM和DLS显示平均直径为85 nm和90-170 nm之间的纳米粒子的球形结构。拉伸和振动带确认 SiO 2的存在在 FTIR 分析中获得。UV-vis 和 PL 光谱的光谱分别在 233 nm 和 555 nm 的最大波长处获得。SiO 2纳米颗粒对大肠杆菌和金黄色葡萄球菌的抗微生物作用揭示了显着的反应,这使得它们可用于许多生物医学应用,如药物输送。SiO 2纳米颗粒对人肺上皮(A549)细胞系的细胞毒性揭示了它们的无毒行为。

更新日期:2021-08-02
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