ABSTRACT

Metabolic reprogramming is common in various cancers. Targeting metabolism to treat tumors is a hot research topic at present. Among them, changes in glucose metabolism in cancer have been widely studied. The Warburg effect maintains a high metabolic level in the tumor, accompanied by changes in glucose transporters. The transmembrane transport of sugar was previously thought to be mediated by SGLT and GLUT. Recently, the Solute Carrier Family(SLC) 45 family may be the third sugar transporter. But the role and value of the SLC45 family in melanoma, a highly malignant skin tumor, is unclear. Our study found that the four members of the SLC45 family, SLC45A1-SLC45A4, were differentially expressed in melanoma, but only SLC45A2 and SLC45A3 had prognostic guiding values. Further analysis revealed that the co-expression patterns of SLC45A2 and SLC45A3 were enriched in multiple metabolic pathways, suggesting their potential role in melanoma. In addition, SLC45A2 and SLC45A3 are also associated with immune cell infiltration. In conclusion, SLC45A2 and SLC45A3 are good prognostic indicators for melanoma and have guiding value for the treatment of melanoma in the future.

 抽象的

代谢重编程在各种癌症中很常见。靶向代谢治疗肿瘤是目前的研究热点。其中，癌症中葡萄糖代谢的变化已被广泛研究。瓦尔堡效应使肿瘤维持高代谢水平，并伴随着葡萄糖转运蛋白的变化。糖的跨膜转运以前被认为是由 SGLT 和 GLUT 介导的。最近，溶质载体家族（SLC）45家族可能是第三种糖转运蛋白。但SLC45家族在黑色素瘤（一种高度恶性的皮肤肿瘤）中的作用和价值尚不清楚。我们的研究发现，SLC45家族的四个成员SLC45A1-SLC45A4在黑色素瘤中存在差异表达，但只有SLC45A2和SLC45A3具有预后指导价值。进一步分析表明，SLC45A2 和 SLC45A3 的共表达模式在多种代谢途径中丰富，表明它们在黑色素瘤中的潜在作用。此外，SLC45A2和SLC45A3也与免疫细胞浸润有关。综上所述，SLC45A2和SLC45A3是黑色素瘤良好的预后指标，对未来黑色素瘤的治疗具有指导价值。