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Throwing open the doors of perception: The role of dopamine in visual processing
European Journal of Neuroscience ( IF 2.7 ) Pub Date : 2021-08-02 , DOI: 10.1111/ejn.15408 Alexander Woolrych 1 , Nicolas Vautrelle 1 , John N. J. Reynolds 1 , Louise C. Parr‐Brownlie 1
European Journal of Neuroscience ( IF 2.7 ) Pub Date : 2021-08-02 , DOI: 10.1111/ejn.15408 Alexander Woolrych 1 , Nicolas Vautrelle 1 , John N. J. Reynolds 1 , Louise C. Parr‐Brownlie 1
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Animals form associations between visual cues and behaviours. Although dopamine is known to be critical in many areas of the brain to bind sensory information with appropriate responses, dopamine's role in the visual system is less well understood. Visual signals, which indicate the likely occurrence of a rewarding or aversive stimulus or indicate the context within which such stimuli may arrive, modulate activity in the superior colliculus and alter behaviour. However, such signals primarily originate in cortical and basal ganglia circuits, and evidence of direct signalling from midbrain dopamine neurons to superior colliculus is lacking. Instead, hypothalamic A13 dopamine neurons innervate the superior colliculus, and dopamine receptors are differentially expressed in the superior colliculus, with D1 receptors in superficial layers and D2 receptors in deep layers. However, it remains unknown if A13 dopamine neurons control behaviours through their effect on afferents within the superior colliculus. We propose that A13 dopamine neurons may play a critical role in processing information in the superior colliculus, modifying behavioural responses to visual cues, and propose some testable hypotheses regarding dopamine's effect on visual perception.
中文翻译：
打开感知之门：多巴胺在视觉处理中的作用
动物在视觉线索和行为之间形成关联。尽管已知多巴胺在大脑的许多区域中对将感官信息与适当的反应结合起来至关重要，但多巴胺在视觉系统中的作用却鲜为人知。视觉信号，指示奖励或厌恶刺激的可能发生或指示此类刺激可能到达的环境，调节上丘的活动并改变行为。然而，这些信号主要起源于皮质和基底神经节回路，缺乏从中脑多巴胺神经元到上丘的直接信号传导的证据。相反，下丘脑 A13 多巴胺神经元支配上丘，多巴胺受体在上丘中差异表达，D1受体在表层，D2受体在深层。然而，A13 多巴胺神经元是否通过对上丘内传入神经的影响来控制行为仍然未知。我们提出 A13 多巴胺神经元可能在处理上丘信息、修改对视觉线索的行为反应方面发挥关键作用，并提出了一些关于多巴胺对视觉感知影响的可测试假设。
更新日期：2021-09-21
中文翻译：
打开感知之门：多巴胺在视觉处理中的作用
动物在视觉线索和行为之间形成关联。尽管已知多巴胺在大脑的许多区域中对将感官信息与适当的反应结合起来至关重要，但多巴胺在视觉系统中的作用却鲜为人知。视觉信号，指示奖励或厌恶刺激的可能发生或指示此类刺激可能到达的环境，调节上丘的活动并改变行为。然而，这些信号主要起源于皮质和基底神经节回路，缺乏从中脑多巴胺神经元到上丘的直接信号传导的证据。相反，下丘脑 A13 多巴胺神经元支配上丘，多巴胺受体在上丘中差异表达，D1受体在表层，D2受体在深层。然而，A13 多巴胺神经元是否通过对上丘内传入神经的影响来控制行为仍然未知。我们提出 A13 多巴胺神经元可能在处理上丘信息、修改对视觉线索的行为反应方面发挥关键作用，并提出了一些关于多巴胺对视觉感知影响的可测试假设。
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