Doxorubicin (DOX) is used as an anticancer drug despite its several side effects, especially its irreversible impacts on cardiotoxicity. Coenzyme Q10 (Q10) as a powerful antioxidant and lisinopril (LIS) as an angiotensin-converting enzyme inhibitor seem to provide protection against DOX-induced cardiotoxicity. Therefore, this study aimed to assess the cardioprotective effects of Q10 and LIS against DOX-induced cardiotoxicity in rats. Adult male Sprague–Dawley rats were randomly assigned into the control, LIS, Q10, DOX, DOX + LIS, and DOX + Q10 groups. On day 21, ECG was recorded and the right ventricle was dissected for evaluation of catalase activity and malondialdehyde (MDA) concentration. Additionally, the left ventricle and the sinoatrial (SA) node were dissected to assess the stereological parameters. The results of ECG indicated bradycardia and increase in QRS duration and QT interval in the DOX group compared to the control group. Meanwhile, the total volumes of the left ventricle, myocytes, and microvessels and the number of cardiomyocyte nuclei decreased, whereas the total volume of the connective tissue and the mean volume of cardiomyocytes increased in the DOX group. On the other hand, the SA node and the connective tissue were enlarged, while the volume of the SA node nuclei was reduced in the DOX group. Besides, catalase activity was lower and MDA concentration was higher in the DOX‐treated group. Q10 could recover most stereological parameters, catalase activity, and MDA concentration. LIS also prevented some stereological parameters and ECG changes and improved catalase activity and MDA concentration in the DOX group. The findings suggested that Q10 and LIS exerted cardioprotective effects against DOX-induced cardiac toxicity.

尽管阿霉素 (DOX) 有多种副作用，尤其是对心脏毒性有不可逆转的影响，但仍被用作抗癌药物。辅酶 Q10 (Q10) 作为一种强大的抗氧化剂，赖诺普利 (LIS) 作为一种血管紧张素转换酶抑制剂，似乎可以针对 DOX 引起的心脏毒性提供保护。因此，本研究旨在评估 Q10 和 LIS 对 DOX 诱导的大鼠心脏毒性的心脏保护作用。成年雄性 Sprague-Dawley 大鼠被随机分为对照组、LIS、Q10、DOX、DOX + LIS 和 DOX + Q10 组。第21天，记录心电图并解剖右心室以评估过氧化氢酶活性和丙二醛(MDA)浓度。此外，解剖左心室和窦房结以评估体视学参数。心电图结果显示，与对照组相比，DOX 组出现心动过缓、QRS 时限和 QT 间期增加。同时，DOX组的左心室、肌细胞和微血管的总体积以及心肌细胞核的数量减少，而结缔组织的总体积和心肌细胞的平均体积增加。另一方面，DOX组SA结和结缔组织增大，而SA结核体积减小。此外，DOX治疗组过氧化氢酶活性较低，MDA浓度较高。 Q10可以恢复大部分体视学参数、过氧化氢酶活性和MDA浓度。 LIS 还阻止了 DOX 组的一些体视学参数和心电图变化，并改善了过氧化氢酶活性和 MDA 浓度。研究结果表明，Q10 和 LIS 对 DOX 引起的心脏毒性具有心脏保护作用。