Some pain-related information is processed preferentially in the right cerebral hemisphere. Considering that functional lateralization can be affected by handedness, spinal and cerebral pain-related responses may be different between right- and left-handed individuals. Therefore, this study aimed to investigate the cortical and spinal mechanisms of nociceptive integration when nociceptive stimuli are applied to right -handed vs. left -handed individuals. The NFR, evoked potentials (ERP: P45, N100, P260), and event-related spectral perturbations (ERSP: theta, alpha, beta and gamma band oscillations) were compared between ten right-handed and ten left-handed participants. Pain was induced by transcutaneous electrical stimulation of the lower limbs and left upper limb. Stimulation intensity was adjusted individually in five counterbalanced conditions of 21 stimuli each: three unilateral (right lower limb, left lower limb, and left upper limb stimulation) and two bilateral conditions (right and left lower limbs, and the right lower limb and left upper limb stimulation). The amplitude of the NFR, ERP, ERSP, and pain ratings were compared between groups and conditions using a mixed ANOVA. A significant increase of responses was observed in bilateral compared with unilateral conditions for pain intensity, NFR amplitude, N100, theta oscillations, and gamma oscillations. However, these effects were not significantly different between right- and left-handed individuals. These results suggest that spinal and cerebral integration of bilateral nociceptive inputs is similar between right- and left-handed individuals. They also imply that pain-related responses measured in this study may be examined independently of handedness.

一些与疼痛相关的信息优先在右脑半球进行处理。考虑到功能性偏侧化会受到惯用手的影响，右手和惯用左手的个体之间的脊髓和大脑疼痛相关反应可能不同。因此，本研究旨在研究当伤害感受刺激应用于惯用右手和惯用左手的个体时，伤害感受整合的皮质和脊髓机制。在十名右手和十名左手参与者之间比较了 NFR、诱发电位（ERP：P45、N100、P260）和事件相关的光谱扰动（ERSP：theta、alpha、beta 和 gamma 波段振荡）。下肢和左上肢的经皮电刺激引起疼痛。刺激强度在 5 种平衡条件下分别调节，每种 21 种刺激：三种单侧（右下肢、左下肢和左上肢刺激）和两种双侧条件（左右下肢、右下肢和左上肢）肢体刺激）。使用混合方差分析比较组和条件之间的 NFR、ERP、ERSP 和疼痛等级的幅度。与单侧条件相比，双侧疼痛强度、NFR 幅度、N100、θ 振荡和伽马振荡的反应显着增加。然而，这些影响在惯用右手的人和惯用左手的人之间没有显着差异。这些结果表明，在惯用右手和惯用左手的个体之间，双侧伤害性输入的脊髓和大脑整合是相似的。