The effects of the tail suspension and reloading on the protein and lipid metabolism in muscle and blood in type 2 diabetes mellitus (T2DM) are unclear. This study evaluated the hypothesis that skeletal muscle catabolism is greater in T2DM than in non-diabetes mellitus (non-DM) rats and that the activity-dependent changes in the intramuscular lipid accumulation and blood lipid profile are poorer in T2DM than in non-DM rats. T2DM and non-DM rats were suspended for two weeks followed by reloading for two weeks. The muscle and blood were then examined. In contrast to our hypothesis, there was no marked difference between the T2DM and non-DM groups in terms of the skeletal muscle catabolism and activity-dependent changes in intramuscular lipid accumulation. However, the blood lipid profile increased in the T2DM group compared to the non-DM group. One interesting finding in this study was the decrease in non-high-density lipoprotein (non-HDL) cholesterol levels after one week of reloading followed by a significant increase in the non-HDL cholesterol levels after two weeks of reloading in the T2DM group. These results suggest that a dramatic increase in activity after a period of inactivity may rapidly improve the blood lipid profile in T2DM rats.

中文翻译：

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2型糖尿病大鼠悬尾重载后血脂变化

悬尾和重载对2型糖尿病（T2DM）肌肉和血液中蛋白质和脂质代谢的影响尚不清楚。本研究评估了以下假设：T2DM 中的骨骼肌分解代谢比非糖尿病（非 DM）大鼠更大，并且 T2DM 中肌肉内脂质积累和血脂谱的活动依赖性变化比非 DM 差。老鼠。T2DM 和非 DM 大鼠暂停两周，然后重新加载两周。然后检查肌肉和血液。与我们的假设相反，T2DM 组和非 DM 组在骨骼肌分解代谢和肌内脂质积累的活动依赖性变化方面没有显着差异。然而，与非 DM 组相比，T2DM 组的血脂谱增加。本研究中一个有趣的发现是，在 T2DM 组再加载一周后，非高密度脂蛋白 (non-HDL) 胆固醇水平降低，然后在再加载两周后非高密度脂蛋白胆固醇水平显着增加。这些结果表明，在一段时间不活动后，活动的显着增加可能会迅速改善 T2DM 大鼠的血脂谱。